epilepsy/obesity

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Obesity is a common comorbidity for pediatric patients with untreated, newly diagnosed epilepsy.

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OBJECTIVE This study aimed to determine the frequency and factors associated with obesity in a cohort of children and adolescents with newly diagnosed untreated epilepsy. METHODS Body mass index (BMI) Z-scores and percentiles, both adjusted for age, were used as measures for obesity. Potential

Obesity and endocrine disorders in women taking valproate for epilepsy.

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We recently reported the frequent occurrence of polycystic ovaries and hyperandrogenism in women taking valproate for epilepsy, especially when the medication was started before the age of 20 years. In the present study we evaluated the association of obesity and hyperinsulinemia with

Predictors of behavioral dysregulation and social dysfunction in pediatric patients with epilepsy and obesity: Developmental timing matters

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Childhood obesity has been associated with greater risks of psychopathology, including externalizing behaviors and social dysfunction. However, there has been limited research on the effect of obesity on psychosocial functioning among pediatric patients with epilepsy. Accordingly, this study aimed

Topiramate: Effects on cognition in patients with epilepsy, migraine headache and obesity.

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This paper reviews the clinical implications of topiramate (TPM)-induced cognitive deficits in patients with epilepsy, migraine headache, obesity, and in normal populations, followed by reviews of the literature describing the reversal of such deficits upon medication discontinuation. It also

Is prepregnancy obesity associated with risk of cerebral palsy and epilepsy in children?

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We conducted a retrospective cohort study to investigate the association between prepregnancy obesity in women and risk of cerebral palsy and epilepsy in their children using data from the South Carolina Medicaid program. The cohort included 83,901 maternal-child pairs; 100 cases of cerebral palsy

Obesity and its association with generalised epilepsy, idiopathic syndrome, and family history of epilepsy.

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Aim. Previous studies support the concept that obesity is a common comorbid condition in patients with epilepsy (PWE). In this study, we present the body mass index (BMI) and data from a survey to assess physical activity in a sample of PWE from an epilepsy clinic. Methods. Between June of 2011 and

Overweight in epilepsy as a risk factor for pregnancy and delivery complications.

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To investigate whether prepregnancy overweight in women with epilepsy increases their risk for complications during pregnancy and delivery. This study is based on The Norwegian Mother and Child Cohort Study (MoBa) linked to the Medical Birth Registry of Norway. A diagnosis of epilepsy was reported

Obesity in adults with epilepsy.

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Sixty-eight percent of the US adult population is overweight, and 35% is obese. The rate of obesity in patients with epilepsy is unknown. Its determination was the goal of the present study. Weight and height were measured, and body mass index (BMI) was calculated in all newly evaluated patients

Metabolic gene expression changes in the hippocampus of obese epileptic male rats in the pilocarpine model of temporal lobe epilepsy.

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Chronically epileptic male adult rats in the pilocarpine model of temporal lobe epilepsy (TLE), exhibited gross expansion of abdominal fat mass and significant weight gain several months after induction of status epilepticus (SE) when compared to control rats. We hypothesized that epileptogenesis

Evaluation of factors influencing obesity and the effect of a 12-week home-based exercise program in people with epilepsy - Randomized control trial

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Background: Association of obesity, quality of life (QoL), and physical fitness in people with epilepsy (PWE) is rarely reported. We evaluate the effect of a 12-week home-based exercise program on weight reduction and physical capacity in PWE.

Insomnia symptoms and obesity are associated with aggression independent of depression in patients with epilepsy.

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There has been little research conducted into aggression in persons with epilepsy (PWE). We determine whether sleep disturbances and obesity are associated with aggression in PWE independent of psychological distress.This was a cross-sectional study. The

Low serum leptin level is associated with zonisamide-induced weight loss in overweight female epilepsy patients.

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Because iatrogenic obesity may hinder medication compliance, it would be a reasonable approach to consider antiepileptic drugs (AEDs) that promote weight loss in overweight patients. We performed an open-label, observational study to assess the effects of zonisamide on weight in overweight female

Serum Insulin and Leptin Levels in Children with Epilepsy on Valproate-associated Obesity.

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BACKGROUND Weight gain is a common adverse effect of sodium valproic acid (VPA) in children with epilepsy. Several mechanisms of VPA-induced obesity have been suggested such as increased appetite, facultative thermogenesis, and elevated insulin and leptin levels. In this study, we aimed to

[The prevalence of obesity and metabolic syndrome in paediatric patients with epilepsy treated in monotherapy with valproic acid].

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BACKGROUND Valproic acid (VPA) is a useful antiepileptic drug for controlling different types of epilepsy. It has several side effects and is associated to increased body weight, as well as metabolic and endocrine disorders, including metabolic syndrome. OBJECTIVE To determine the prevalence of

Effects of valproic acid and levetiracetam monotherapy on carotid intima-media and epicardial adipose tissue thickness in non-obese children with epilepsy.

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The aim of the study was to investigate the risk of subclinical atherosclerosis independent from obesity and high blood lipid levels in pediatric patients with idiopathic epilepsy receiving valproic acid or levetiracetam monotherapy by evaluating carotid intima-media thickness (CIMT)

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