Cataract surgery will be performed using standard anesthesia and phacoemulsification techniques. A clear corneal incision should be used for instrumentation. The choice of viscoelastics to maintain the anterior chamber is left to the surgeon's discretion. The viscoelastic will be washed-out of the capsular bag after IOL insertion. Further cohesive viscoelastic material will be injected through the main wound between the anterior capsule and iris, until the iris is close to or touching the cornea. A curved ECP probe will be inserted through the corneal incision wound/wounds and 360° of the anterior section of the ciliary processes will be treated. The power setting will be varied according to tissue response (starting power of 250 mW with continuous setting). 'Pops' should be avoided (but recorded) but no indentation used during treatment.
Intracameral cefuroxime and dexamethasone will be injected into the anterior chamber and sutures used to close the incisions as required.

Cataract surgery will be performed using standard anesthesia and phacoemulsification techniques. A clear corneal incision should be used for instrumentation. The choice of viscoelastics to maintain the anterior chamber is left to the surgeon's discretion. For this study, monofocal IOLs are required.

Glaucoma Open-Angle Primary

Cataract

A clear corneal incision should be used for instrumentation. The choice of viscoelastics to maintain the anterior chamber is left to the surgeon's discretion.
Phacoemulsification energy used during the cataract surgery will be recorded. If the patient has been randomised to ECP laser, the viscoelastic will be washed-out of the capsular bag. Further cohesive viscoelastic material will be injected through the main wound between the anterior capsule and iris, until the iris is close to or touching the cornea. A curved ECP probe will be inserted through the corneal incision wound/wounds and 360° of the anterior section of the ciliary processes will be treated. The power setting will be varied according to tissue response (starting power of 250 mW with continuous setting). 'Pops' should be avoided (but recorded) but no indentation used during treatment. Final power used and duration of surgery will be recorded.

Phacoemulsification+ Endoscopic cyclophotocoagulation (ECP) laser

Comparing the Effectiveness of Phacoemulsification + ECP Laser and Phacoemulsification Alone for Glaucoma Patients

Comparing the Effectiveness of Phacoemulsification + ECP Laser and Phacoemulsification Alone for the Treatment of Open Angle Glaucoma in Patients With Cataract - a Randomised Controlled Trial

Change in post-washout IOP of at least 2.7 mmHg at 24 months from baseline. The IOP will be measured using Goldmann applanation tonometer at each visit.

The % of patients with reduction of mean diurnal IOP of ≥ 20% from baseline at 24 months following medication washout.The IOP will be measured using Goldmann applanation tonometer at 9 am and 11 am at baseline, 12 and 24 months follow up visits. Mean diurnal IOP will be calculated using statistics package.

Change in number of glaucoma medication used at 24 months from baseline.

Time reductions - If using ECP as the new standard of care (instead of drainage surgery), time reductions operatively will allow for more surgical procedures to be performed in theatres, which will benefit NHS Trusts.
Change in number of glaucoma therapeutic drugs - Cost savings can be naturally made if the surgical procedure is sustainable over a period of 2 years. Clinic, GP and pharmacy visits required will be assessed using patient questionnaire.

Rate of complications will be recorded and compared between two groups. Safety outcomes include: Loss of > 2 lines of BCVA, slit lamp and fundus examination findings, the incidence of complications and adverse events.

Guy's and St Thomas' NHS Foundation Trust

King's College London

Imperial College London

including 51 women who will receive a prefilled syringe with two milliliters (8 mg) of dexamethasone intravenously.

including 51 women who will receive a prefilled syringe with two milliliters of distilled water intravenously.

Induction of Labor Affected Fetus / Newborn

a prefilled syringe with two milliliters (8 mg) of dexamethasone intravenously

Dexamethasone

a prefilled syringe with two milliliters of distilled water intravenously.

Distilled Water

Ain Shams University

Dexamethasone and Induction of Delivery

Dexamethasone Effect on Induction Delivery Interval at Term Randomized Controlled Trial

Mean time of interval between the initiation of induction and the delivery of the fetus in the two groups.

Mean time of duration of the first stage of labor in the two groups.

Mean time of duration of the second stage of labor in the two groups.

Mean time of duration of the third stage of labor in the two groups.

Mean of APGAR score at 1 and 5 minutes for fetus in the two groups.

Percentage of postpartum adverse effects in both group.

samar sayed el sayed

Gynecologist and Obstetrician

a single dose of carbetocin (100 μg in 1 mL ampoule, Pabal) given intravenously after delivery of anterior shoulder

misoprostol (600 μg, 3 tables) sublingually after the delivery of the anterior shoulder of the baby.

Severe Pre-eclampsia, Postpartum Condition or Complication

given after the delivery of the anterior shoulder of the baby.

misoprostol

given after delivery of anterior shoulder

carbetocin

Benha univesity hospital

Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol

Carbetocin in Preventing Postpartum Bleeding in Women With Severe Preeclampsia.

khalid abd aziz mohamed

lecturer

During the trial implant of Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic Migraine, the 2 leads will be positioned to cover the C2-C3 cervical levels.
Over the following 2 weeks, the investigator will optimize therapy delivery by identifying the stimulation settings providing maximal headache pain relief.
The subject will be asked to attend the clinic at the end of the trial period. Together with his/her physician, the subject will discuss his/her experience over the past 2 weeks (satisfaction with the therapy), and decide whether or not move forward with a Nevro Senza IPG.
The Nevro Senza IPG will be implanted in the buttock or abdomen area as outlined in the Physician's Manual. Fluoroscopy and impedance measurements may be used during the procedure to confirm lead placement and location.
Before hospital discharge, the IPG will be programmed with the optimal settings identified during the trial phase.

Refractory Chronic Migraine

Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic Migraine

Sant'Andrea Hospital

A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine

Change of frequency in headache days from baseline

Change of frequency in migraine days from baseline

Change in frequency of moderate/severe headache days from baseline

Change in headache pain Visual Analog Scale (VAS) score from baseline

Change in Migraine Disability Assessment (MIDAS) Score from baseline

Change in frequency of triptans intake from baseline

Patient Global Impression of Change (PGIC)

Change in the number of sleep disturbances per night from baseline

Incidence of device-related adverse events

Paolo Martelletti

Professor, Internal Medicine

University of Roma La Sapienza

King's College Hospital NHS Trust

The main study arm will be examining how well a 50% Nitrous Oxide/50% Oxygen gas mixture is in reducing labor pains in term labor patients with less than 5 cm cervical dilation, compared to 2mg of Butorphanol (a common synthetic opiod used for labor pains in this setting).

Labor Pain

The gas mixture is provided via the Sedara portable gas delivery system. This system is equipped with a non-rebreather mask which the patient holds over their mouth and nose. The delivery of the gas is only triggered by the patient's spontaneous breath. The gas machine will be provided to the patient to use as much as they like during the 60 minutes data collection period. The only dose which the machine allows to be administered is 50% Nitrous Oxide/50% oxygen.

50% Nitrous Oxide/50% Oxygen

West Penn Hospital

Comparing Sedara to Butorphanol in Early Labor

Comparing Pain Relief in Early Labor: Nitrous Oxide Versus Butorphonol Study

The primary outcome measure of pain relief will be measured using a 100mm visual analog scale (VAS) immediately prior to administration of the test medication (either Sedara or butorphanol) and again at 5, 15, 30 and 60 minutes following the medication start time.

Secondary outcome measures collected include maternal reported level nausea, sedation, and overall satisfaction with analgesia using the Visual Analog Scores Scale at 0, 5, 15, 30 and 60 minutes.

fetal distress/headache

Comparing the Effectiveness of Phacoemulsification + ECP Laser and Phacoemulsification Alone for Glaucoma Patients

Dexamethasone and Induction of Delivery

Prevention of Postpartum Hemorrhage in Patients With Severe Preeclampsia Using Carbetocin Versus Misoprostol

A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine

Comparing Sedara to Butorphanol in Early Labor

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