hearing loss/fatigue

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L-Citrulline Dose Finding Safety Study in MELAS

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The human body is made of many cells and each cell contains many mitochondria. Mitochondria are called the powerhouses of the cell, because they produce the energy needed for a cell to be healthy and function the way it is meant to. Diseases of the mitochondria affect the way the tissues and cells

Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease

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Mycobacterium avium complex (MAC) are a subset of nontuberculous mycobacteria (NTM), environmental bacteria that can cause chronic, debilitating pulmonary disease, primarily affecting those over age 60. The goals of treatment are to improve symptoms, stop disease progression, and clear the

Protocol for Observational Study of Post op Delirium Following Total Joint Arthroplasties

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BACKGROUND Modern studies have evaluated the risk factors and incidence of postoperative delirium in post-TJA patients. In current literature, incidence ranges from 0-10%. However, the epidemiology of these studies mainly focused on non-Asian populations. The investigators hope to determine both the

GDF-15 as a Biomarker for Mitochondrial Disease

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BACKGROUND Energy insufficiency: Mitochondrial and metabolic myopathies are inherited diseases compromising cellular energy metabolism, which especially affects skeletal muscle because of its high energy needs. Chemical energy is stored in the body as adenosine triphosphate (ATP), which is derived

Perinatal Stroke: Understanding Brain Reorganization

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Background and Significance Perinatal stroke affects more than1 in 2,300 live births. Perinatal stroke is the most common cause of hemiparetic cerebral palsy (CP). Even with prompt behavioral therapy, ongoing significant residual motor impairments are common in these children. In this case,

Role of the Auditory Efferent System in Auditory Perceptual Learning

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The goal of this study is to determine the impact of an auditory training program on the function of the inner ear and auditory brainstem. In normal-hearing individuals, the medial olivocochlear (MOC) branch of the auditory efferent system appears to aid with hearing signals in noise. A previous

Possible Role of Chloroquine to Induce a Complete Remission in the Treatment of Autoimmune Hepatitis: a Randomized Trial

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Autoimmune hepatitis (AIH) is a chronic disease with a progressive destruction of hepatic parenchyma, leading to cirrhosis and high mortality in the absence of specific treatment. It has been demonstrated that the treatment with corticosteroids and azathioprine provides clinical and laboratory

Swiss Austrian German Testicular Cancer Cohort Study - SAG TCCS

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Objectives Primary objective The primary objective is to determine the diagnostic performance and the clinical impact of a variety of tests, including conventional radiographs, computer tomographies (CT), abdominal ultrasound, serum tumour markers (AFP, beta-HCG and LDH) and clinical signs and

A Trial of Surgery and Fractionated Re-Irradiation for Recurrent Ependymoma

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Stratification for treatment will be determined when radiation therapy planning is initiated. Patients will be stratified for outcome according to diagnosis and prior therapy. - Stratum 1 (initial pattern of failure is local); disease confined to primary site; age >12 months at time of enrollment to

CHLOROQUINE FOR MAINTENANCE REMISSION OF AUTOIMMUNE HEPATITIS

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Treatment of Iron Overload With Deferasirox (Exjade) in Hereditary Hemochromatosis and Myelodysplastic Syndrome

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The two most important causes of iron overload disease in humans are the iron-loading disorder hereditary hemochromatosis (HC), and transfusional siderosis in patients with chronic hematological diseases like myelodysplastic syndrome (MDS), thalassemia, and leukemia. Hemochromatosis. In HC the

Weekly Cetuximab/RT Versus Weekly Cisplatin/RT in HPV-Associated Oropharyngeal Squamous Cell Carcinoma

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Human Papilloma Virus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing in incidence and has an improved prognosis compared to other head and neck malignancies when treated with standard combination chemoradiation. The current standard regimen of high dose cisplatin and

A Randomized Trial to Prevent Congenital Cytomegalovirus (CMV)

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Cytomegalovirus (CMV) is the most common congenital infection, with approximately 44,000 congenitally infected infants in the U.S. per year. A substantial proportion of these infants will die or suffer permanent injury as a result of their infection. The severity of congenital infection is greatest

Mindfulness Based Tinnitus Reduction (MBTR): A Symptom Perception Shift Program

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Tinnitus is a medical term for acoustical perceptions heard in the ear(s) or head, not produced by external sound. This sound can be experienced as a ringing, buzzing, whooshing, or hissing. Estimates suggest that as many as 50 million people in the United States experience tinnitus to some degree.

A Trial of Clay Weight on the Ear Drum for Patulous Eustachian Tube

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The Eustachian tube is a tube that connects the back of the nose with the ear. Its job is to keep the pressure on the inside of the eardrum close to the pressure outside the eardrum, so that the eardrum can vibrate properly. Usually this tube is closed, but it opens briefly during swallowing. In the

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