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Effect of FODMAPs on Mucosal Inflammation in IBS Patients

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Up to 15 % of adults in Western society suffer from irritable bowel syndrome (IBS), and it is the second leading cause, behind the common cold, of workplace absenteeism. This proposal addresses critical knowledge gaps in our understanding of IBS mechanisms. What environmental triggers cause pain

Effects of Cyproheptadine on Growth and Behavior in Pediatric Feeding Disorders

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BACKGROUND, SIGNIFICANCE, AND RATIONALE Failure to thrive or inadequate weight gain is a frequent complaint amongst patients seen by general pediatricians and pediatric gastroenterologists. The reasons behind this diagnosis vary widely including, but not limited to feeding disorders of diverse

Ibrutinib in Treating Patients With Advanced Systemic Mastocytosis

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PRIMARY OBJECTIVE: Evaluate the response rate to ibrutinib in patients with advanced systemic mastocytosis (SM) (aggressive systemic mastocytosis [ASM] or mast cell leukemia [MCL], or SM-associated hematologic non-mast cell disorder [AHNMD]) by the end of 6 cycles (6 months). SECONDARY OBJECTIVES: -

Tolerance to a New Free Amino Acid-based Formula in Children With IgE or Non-IgE-mediated Cow's Milk Allergy

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Prospective controlled study including pediatric patients (≤14 years of age) with a recent diagnosis of IgE- or non-IgE-mediated CMA, confirmed by positive oral food challenge or anaphylaxis in the 2 months prior to enrollment and under good clinical control. Children with concomitant chronic

Safety and Efficacy of AST-120 in Patients With Non-Constipating Irritable Bowel Syndrome

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Patients experiencing non-constipating IBS will be randomized to one of two arms in the study: the experimental drug AST-120 or placebo. Patients will take 2g of AST-120 or placebo three times per day for eight weeks. After the 8 week course, patients will receive an additional 8 weeks single blind

A Trial Comparing the Effect of Oral Dimenhydrinate Versus Placebo in Children With Gastroenteritis

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STRUCTURED RESEARCH ABSTRACT Background: The use of antiemetic drugs to treat nausea and vomiting during an episode of acute gastroenteritis in children remains controversial. To date, there have been a limited number of clinical trials studying this subject matter and health authorities'

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