histamine/seizures

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The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats.

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The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled

Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats.

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This study was performed to investigate whether or not endogenous histamine can protect seizure development of pentylenetetrazole (PTZ)-induced kindling in rats. An intracerebroventricular (i.c.v.) injection with clobenpropit (5 and 10 microg), a representative H(3)-antagonist, significantly

[Involvement of endogenous histamine in modulatory effect of morphine on seizure susceptibility in mice].

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OBJECTIVE To investigate the modulatory effects of morphine on the susceptibility to pentylenetetrazole-induced seizures, and the involvement of endogenous histamine in this process. METHODS Both the wild-type (WT) mice and histidine decarboxylase (a key enzyme for histamine biosynthesis) deficient

Thioperamide, a selective histamine H3 receptor antagonist, protects against PTZ-induced seizures in mice.

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The effect of selective histamine H3-receptor antagonist thioperamide was studied on PTZ-induced seizures in mice. Thioperamide significantly protected clonic seizures induced by PTZ in a dose-dependent manner. The effect of thioperamide was completely countered by pretreatment with R

Effect of histamine receptor antagonists on aminophylline-induced seizures and lethality in mice.

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The aim of this study was to evaluate the effects of H(1) (antazoline and astemizole) or H(2) (cimetidine and famotidine) histamine receptor antagonists on the clonic phase, tonic seizures and morality of mice challenged with aminophylline to induce convulsions in mice. Moreover, the total plasma

Influences of histamine H1 receptor antagonists on maximal electroshock seizure in infant rats.

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The influences of histamine H1 receptor antagonists on maximal electroshock seizure were studied using infant rats. In this study, electroconvulsion was induced by stimulating rats using ear-clip electrodes, and the durations of electroencephalogram (EEG) seizure, tonic extensor (TE) seizure and

Histamine H1 antagonists and clinical characteristics of febrile seizures.

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BACKGROUND The purpose of this study was to determine whether seizure susceptibility due to antihistamines is provoked in patients with febrile seizures. METHODS The current descriptive study was carried out from April 2009 to February 2011 in 250 infants and children who visited the Madinah

Inhibitory effect of iodophenpropit, a selective histamine H3 antagonist, on amygdaloid kindled seizures.

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The effect of histamine H(3) antagonist, iodophenpropit on amygdaloid kindled seizures in rats was studied in comparison with those of other H(3) antagonists. Under pentobarbital anesthesia, the rats were fixed to a stereotaxic apparatus and bipolar electrodes were implanted into the amygdala.

Histamine in cerebrospinal fluid of children with febrile convulsions.

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Febrile convulsions (FC) are frequent acute neurologic disturbances of childhood. The cellular and neurochemical mechanisms causing FC are unclear. Among other mechanisms, the CNS histamine (HA) has been suggested to participate in seizure control and thermoregulation. We evaluated the possible role

Mechanism of the inhibitory effect of histamine on amygdaloid-kindled seizures in rats.

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OBJECTIVE The mechanism of the inhibitory effect of histamine on amygdaloid-kindled seizures was investigated in rats. METHODS Under pentobarbital anesthesia, rats were fixed to a stereotaxic apparatus, and bipolar electrodes were implanted into the right amygdala. A guide cannula made of stainless

Influence of low dietary histamine on seizure development of chemical kindling induced by pentylenetetrazol in rats.

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OBJECTIVE To determine the role of dietary low histamine on the seizure development of pentylenetetrazol (PTZ)-induced kindling in rats. METHODS After 14 d of feeding on a low histamine diet (LH, containing 0.145 mumol/g of histamine), the rats were chemically kindled by repeated intraperitoneal

[Effects between the first-and second-generation histamine H1-antagonists on seizure development of pentylenetetrazole-induced kindling in rats].

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OBJECTIVE To investigate the effects and the mechanisms of the first-generation histamine H(1)-antagonist diphenhydramine and the second-generation histamine H(1)- antagonist fexofenadine on seizure development of pentylenetetrazole (PTZ)-induced kindling in rats. METHODS The first-or

[Role of central histamine in amygdaloid kindled seizures].

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The role of central histamine in amygdaloid kindled seizures in rats was studied. Histamine content in the amygdala was significantly decreased after development of amygdaloid kindling. Intracerebroventricular (i.c.v.) injection of histamine resulted in inhibition of amygdaloid kindled seizures. The

2-Thiazolylethylamine, a selective histamine H1 agonist, decreases seizure susceptibility in mice.

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The effects of intracerebroventricular (ICV) administration of histamine and its selective agonists on electrically and pentylenetetrazole-induced convulsions in mice were studied. The ICV administration of histamine decreased seizure susceptibility on electrically and pentylenetetrazole-induced

Involvement of central histamine in amygdaloid kindled seizures in rats.

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The involvement of central histamine in amygdaloid kindled seizures in rats was investigated using histamine-related compounds. Histamine contents in the amygdala of electrical stimulation site was significantly decreased after development of amygdaloid kindling. Intracerebroventricular (i.c.v.)

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