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St. John's wort attenuates irinotecan-induced diarrhea via down-regulation of intestinal pro-inflammatory cytokines and inhibition of intestinal epithelial apoptosis.

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Diarrhea is a common dose-limiting toxicity associated with cancer chemotherapy, in particular for drugs such as irinotecan (CPT-11), 5-fluouracil, oxaliplatin, capecitabine and raltitrexed. St. John's wort (Hypericum perforatum, SJW) has anti-inflammatory activity, and our preliminary study in the

Nature cures nature: Hypericum perforatum attenuates physical withdrawal signs in opium dependent rats.

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BACKGROUND Hypericum perforatum Linn. (Hypericaceae) (St. John's wort) attenuates opium withdrawal signs. OBJECTIVE To explore the therapeutic potential of Hypericum perforatum in the management of opium-induced withdrawal syndrome. METHODS The effect of the Hypericum perforatum hydro-ethanol

Development of pregnancy in rats treated with Hypericum perforatum.

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St John's wort (Hypericum perforatum) is a medicinal plant used in the treatment of depression and other psychiatric disorders. In the present paper, the toxicity of H. perforatum administered to female rats during the period of organogenesis (day 9-15 of pregnancy) was evaluated. Thirty inseminated

[Evaluation of Hypericum perforatum toxicity when administered to pregnant rats].

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BACKGROUND Saint John's wort (Hypericum perforatum) is a medicinal plant used in the treatment of depression and other psychiatric disorders. OBJECTIVE In the present paper, the toxicity of H. perforatum administered to female rats during organogenesis (9th to 15th day of pregnancy) was

An open-label trial of St. John's Wort (Hypericum perforatum) in obsessive-compulsive disorder.

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BACKGROUND Recent interest in and evidence for the efficacy of St. John's wort (Hypericum perforatum) for the treatment of mild-to-moderate depression has led to speculation about its efficacy in other disorders. Hypericum's mechanism of action is postulated to be via inhibition of the synaptosomal

Bioactive compounds from the aerial parts of Hypericum sampsonii.

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Hypericum sampsonii is an important medicinal plant used in Vietnam to treat many diseases such as backache, burns, diarrhea, and swelling. In order to study the chemical constituents in the aerial parts of H. sampsonii, five compounds, including two xanthones (1-2), and three benzophenones (3-5)

Pharmacokinetics, safety, and antiviral effects of hypericin, a derivative of St. John's wort plant, in patients with chronic hepatitis C virus infection.

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Hypericin is a natural derivative of the common St. Johns wort plant, Hypericum perforatum. It has in vitro activity against several viruses, including bovine diarrhea virus, a pestivirus with structural similarities to hepatitis C virus (HCV). We conducted a phase I dose escalation study to

Identification and treatment of depression in minority populations.

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Depression is a common condition, representing close to 6% of visits to primary care providers. Although minorities are more likely to have chronic depression, they are more likely to be incorrectly diagnosed and less likely to receive treatment when compared to the mainstream population. Screening

Ethnoveterinary medicines used for ruminants in British Columbia, Canada.

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BACKGROUND The use of medicinal plants is an option for livestock farmers who are not allowed to use allopathic drugs under certified organic programs or cannot afford to use allopathic drugs for minor health problems of livestock. METHODS In 2003 we conducted semi-structured interviews with 60

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