inflammation/nicotine

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Investigation of Safety and Efficacy of CARDIO Softgels in Former Smokers and Asthma Patients With COVID-19 Infection

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SARS-CoV-2, a plus-sense single-stranded RNA virus, is the etiologic agent of COVID-19. After an incubation period, which typically lasts for 5-6 days, COVID-19 patients present with a mild illness that lasts for a few days. Common symptoms are reminiscent of the flu, and include fever, dry cough

Mitoquines in COPD

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INTRODUCTION Chronic Obstructive Pulmonary Disease (COPD) is characterized by progressive and hardly reversible obstruction of the airways, which basically affects the small airways (chronic obstructive bronchiolitis), variably associated with destruction of the pulmonary parenchyma (emphysema). 10%

FOUND - Ancillary Study to Smile Protocol NCT03654105

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Prospective and Multicentre Study on Clinical-biological Factors Predictive of Chronic Colon DIverticulitis

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GENERAL CHARACTERISTICS OF THE PROJECT: Despite being a benign pathology, colon diverticulitis represents the fifth most important gastrointestinal pathology and has a great clinical impact on the quality of life of patients and on health expenditure. Understanding a disease involves being able to

The Assessment Of Myocardial Viability Based On CTA/MRI Hybrid Models

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The HYBRIDHEART study is a prospective, observational study that will be conducted in the Laboratory of Advanced Research in Cardiac Multimodal Imaging of Cardio Med Medical Center Tîrgu Mureş, Romania. The project will include 100 subjects with documented ST Segment elevation myocardial infarction

Leptin Infusion and Endothelial Vasomotor Response

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Introduction High BMI and particularly fat mass index are associated with increased risk of coronary artery disease and other cardiovascular conditions, but the underlying mechanisms are not well understood. Endothelial dysfunction precedes atherosclerosis and represents an important link between

Respiratory Effects of E-Cigarettes Among Youth / Young Adults

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Using a 1-year, prospective longitudinal design, 150 youth and young adults aged 15-21 years (100 exclusive-EC users; 50 never-users) will complete 5 laboratory visits (baseline, 3-,6-, 9-, and 12-months) following >12 hours of abstinence, which will include laboratory-based respiratory assessments

A Prospective "Universal" Observational Database for COVID-19

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The principle objective of this observational database is to build research-grade real world data that will serve as platform to advance the scientific understanding and clinical care of patients with COVID-19. 1. Demographic, diagnostic, treatment and outcome data from centers throughout the

Effect of Antiinflammatory Treatment Versus Hand Training on Neuropsychiatric Comorbidity in RA-patients

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Based on the information gained in previous studies the investigators want to examine if; A. anti-inflammatory treatment that target TNF-α or JAK signalling or B. physical training of hands has a positive impact on neuropsychiatric symptoms and morphological changes in the brain caused by RA. To

Investigating Racial Differences in Diet Benefits for Knee Osteoarthritis

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A telephone screening interview will be used to assess each participant's OA status and assessment of the reported duration of knee OA, current and past treatments, comorbid conditions, current medication use, dietary conditions and other exclusion criteria. Eligible, participants will be invited to

Sternal Block With Liposomal Bupivacaine vs. Saline Prior to Incision in Cardiac Surgery

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Background: Prolonged and excessive narcotic usage in the postoperative setting has been linked to multiple complications. Use of complimentary pain management techniques such as regional analgesia can reduce postoperative pain and narcotic usage. This can enhance patient recovery and improve

Roflumilast in Non-CF Bronchiectasis Study (2019)

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In a 4-week crossover study in 38 patients with COPD, roflumilast 500μg daily significantly reduced sputum absolute neutrophil count, IL-8 and neutrophil elastase compared with placebo treatment. Interestingly, the mechanism of anti-neutrophilic inflammation with roflumilast treatment in patients

Periodontal Therapy and Oral-gut-hepatic Axis Cirrhosis: a Randomized Controlled Trial

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The aim of this study is to prospectively determine the association of generalised Stage I & II (initial to moderate) with all-cause and cirrhosis-related mortality in patients with cirrhosis. We also plan to evaluate the oral microbiome and association of oral dysbiosis with complications of

Exercise and Diet Intervention Attenuated Inflammation Through ASC Gene and Inflammatory Markers in Obese Adults

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A randomized clinical trial was conducted in the Institute of Translational Nutrigenetics and Nutrigenomics, Department of Molecular Biology in Medicine, Health Sciences Center, at the University of Guadalajara, Guadalajara, Jalisco, Mexico, from February of 2018 to February of 2019. All

Antibiotic Prophylaxis in High-Risk Arthroplasty Patients

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The purpose of this research study is to investigate whether a 7-day course of an oral, prophylactic antibiotic following elective, primary total hip and knee arthroplasty effectively decreases the risk of periprosthetic joint infection or wound complications following surgery in a patient

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