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liver cirrhosis/obesity

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Compound WS 727713

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TECHNICAL FIELD The present invention relates to a new compound which is useful as a medicament or a cosmetic, to a process for producing the same and to a pharmaceutical composition comprising the same. BACKGROUND ART The melanocortin (MC) is a group of peptide hormones that are derived from

Adamantanamines and neramexane salts of thiomolybdic and thiotungstic acids

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FIELD OF THE INVENTION The present invention concerns the preparation and uses of adamantanamines (e.g. memantine, amantadine and rimantadine) and neramexane(s) salts of thiomolybdic acids and thiotungstic acids. Their pharmaceutical compositions incorporate two complementary, bioavailable

Acylamide compounds having secretagogue or inducer activity of adiponectin

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This application is a CON of PCT/JP2006/302058, filed Feb. 7, 2006. TECHNICAL FIELD OF THE INVENTION The present invention relates to adiponectin inducers or secretagogues, and preventive/therapeutic agents of various diseases by making use of the secretagogue or inducer of adiponectin. More

Use of helminthostachys, ugonins or flavone-based compounds for the treatment or prevention of metabolic diseases

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CROSS-REFERENCE TO RELATED APPLICATION This Application claims priority of Taiwan Patent Application No. 105117782, filed on Jun. 6, 2016, the entirety of which is incorporated by reference herein and made a part of this specification. BACKGROUND 1. Field of the Invention The present disclosure

Substituted benzimidazol-2-ones as vasopressin receptor antagonists and neuropeptide Y modulators

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FIELD OF THE INVENTION This invention relates to novel substituted benzimidazol-2-ones. More particularly, the compounds of the present invention modulate the binding of the peptide hormone vasopressin and neuropeptide Y to their respective receptors and are therefore useful for treating conditions

Prodrugs for liver specific drug delivery

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FIELD OF THE INVENTION The present invention is directed towards novel prodrugs of alcohol, amine, and thiol-containing compounds, to their preparation, to their synthetic intermediates, and to their uses. Prodrugs of the invention may be used to deliver drugs to the liver with high tissue

Prodrugs for liver specific drug delivery

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FIELD OF THE INVENTION The present invention is directed towards novel prodrugs of alcohol, amine, and thiol-containing compounds, to their preparation, to their synthetic intermediates, and to their uses. Prodrugs of the invention may be used to deliver drugs to the liver with high tissue

Compounds as diacylglycerol acyltransferase inhibitors

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FIELD OF INVENTION This invention relates to novel compounds which are inhibitors of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination with weight

Thienopyridone derivatives useful as activators of AMPK

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This application is the U.S. national phase of International Application No. PCT/EP2013/063741, filed 28 Jun. 2013, which designated the U.S. and claims priority to EP Application 12305775.4, filed 29 Jun. 2012; the entire contents of each of which are hereby incorporated by reference. The invention

Compounds as diacylglycerol acyltransferase inhibitors

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FIELD OF INVENTION This invention relates to novel compounds which are inhibitors of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination with weight

Compounds as diacylglycerol acyltransferase inhibitors

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FIELD OF INVENTION This invention relates to novel compounds which are inhibitors of acyl coenzyme A: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy, alone or in combination with weight

Compounds as diacylglycerol acyltransferase inhibitors

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This application is a .sctn.371 of International Application No. PCT/US2013/069024, filed 8 Nov. 2013, which claims the priority of Indian Patent Application No. 3480/DEL/2012, filed 9 Nov. 2012. FIELD OF INVENTION This invention relates to novel compounds which are inhibitors of acyl coenzyme A:

Method for diagnosing hepatic fibrosis

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The present invention concerns methods for diagnosing liver fibrosis in a subject suffering from obesity, or for selecting a subject suffering from obesity for liver biopsy or for treatment. The present invention also pertains to methods for screening a probiotic, a prebiotic, a chemical compound or

Indene derivatives and process for the preparation thereof

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FIELD OF THE INVENTION The present invention relates to a novel indene derivative, which is useful as a modulator of a peroxisome proliferator activated receptor (PPAR), a process for the preparation thereof and a pharmaceutical composition containing same as an active ingredient. BACKGROUND OF THE

Urea compounds and their use as enzyme inhibitors

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FIELD OF THE INVENTION The present invention relates to compounds and their uses, and in particular to compounds and their therapeutic use in the treatment or prevention of conditions having an association with substrates, such as the neurotransmitter anandamide, which are broken down by the fatty
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