metaplasia/obesity

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Could Obesity be a Triggering Factor for Endometrial Tubal Metaplasia to be a Precancerous Lesion?

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Endometrial tubal metaplasia (ETM) is mostly described in conjunction with unopposed estrogen levels, and its association with endometrial hyperplasia and endometrial carcinoma (EC) is striking. Obesity is a risk factor for endometrial hyperplasia and EC development. The aim of this

In healthy volunteers, immunohistochemistry supports squamous to columnar metaplasia as mechanism of expansion of cardia, aggravated by central obesity.

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BACKGROUND Recently, we showed that the length of cardiac mucosa in healthy volunteers correlated with age and obesity. We have now examined the immunohistological characteristics of this expanded cardia to determine whether it may be due to columnar metaplasia of the distal oesophagus. METHODS We

Gastric gland metaplasia after jejunoileal by-pass surgery for morbid obesity.

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A 56-year female is described who developed recurrent oxalate nephrolithiasis six years following jejunoileal by-pass surgery for morbid obesity. Subsequently a revision of the jejunoileal by-pass was performed when it was recognized that the site of the anastomosis showed segmental dilatation

Laparoscopic gastric bypass with remnant gastrectomy in a super-super obese patient with gastric metaplasia: a surgical hazard?

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The endoscopic inaccessibility of the gastric remnant after Roux-en-Y gastric bypass (RYGBP) for morbid obesity represents an important issue for patients with familiar history of gastric cancer (GC) or affected by premalignant lesions, such as intestinal metaplasia. If a different bariatric

Effect of gastric bypass on Barrett's esophagus and intestinal metaplasia of the cardia in patients with morbid obesity.

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Gastric bypass in patients with morbid obesity should be an excellent antireflux procedure, because no acid is produced at the small gastric pouch and no duodenal reflux is present, due to the long Roux-en-Y limb. Five hundred fifty-seven patients with morbid obesity submitted to resectional gastric

Age, smoking and overweight contribute to the development of intestinal metaplasia of the cardia.

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OBJECTIVE To assess the role of Helicobacter pylori (H. pylori), gastroesophageal reflux disease (GERD), age, smoking and body weight on the development of intestinal metaplasia of the gastric cardia (IMC). METHODS Two hundred and seventeen patients scheduled for esophagogastroduodenoscopy were

Barrett's metaplasia in Indian obese male patients with gastro-oesophageal reflux disease.

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Although 10% to 15% of gastro-oesophageal reflex disease (GERD) patients have Barrett's oesophagus, neither the frequency nor the severity of symptoms correlates with the presence of Barrett's epithelium. Age, male sex, white race, and obesity have been implicated in some studies. The studies in

Effect of vertical banded gastroplasty on the natural history of gastritis in patients with morbid obesity: a follow-up study.

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Vertical banded gastroplasty is an accepted surgical treatment for morbid obesity. The aim of this study was to evaluate its effect on the natural history of gastritis, as the occurrence of gastritis and dysplasia have been reported after gastric bypass, another type of bariatric surgery.

Esophageal motor dysfunction and acid exposure in reflux esophagitis are more severe if Barrett's metaplasia is present.

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OBJECTIVE To compare esophageal motor function in patients with reflux esophagitis with controls, and identify patient characteristics that may have a bearing on the severity of esophageal motor dysfunction and acid exposure. METHODS Esophageal motor function was assessed in 60 patients with reflux

Body mass index is associated with Barrett esophagus and cardiac mucosal metaplasia.

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A positive association between body mass index (BMI) and risk of esophageal adenocarcinoma has been reported. Barrett esophagus (BE) is a precursor lesion for esophageal adenocarcinoma. Cardiac mucosa (CM) and BE are both reflux-induced metaplastic columnar epithelia in the esophagus. We

[Pathological gastroesophageal reflux in patients with severe, morbid and hyper obesity].

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BACKGROUND Overweight can be a risk factor for pathological gastroesophageal reflux or hiatal hernia. OBJECTIVE To study the prevalence of gastroesophageal reflux in patients with severe obesity. METHODS Sixty seven patients, 51 female, aged 17 to 56 years old with a body mass index over 35 kg/m2,

Prevalence of Helicobacter pylori infection in a group of morbidly obese Saudi patients undergoing bariatric surgery: a preliminary report.

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OBJECTIVE Earlier reports from Saudi Arabia have shown high prevalence of Helicobacter pylori infection. However, recent studies have documented a reduction in the infection prevalence. No prior study has assessed the prevalence in morbidly obese Saudi patients. We aimed to study the prevalence of

Is it feasible to reach the bypassed stomach after Roux-en-Y gastric bypass for morbid obesity? The use of the double-balloon enteroscope.

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OBJECTIVE Endoscopic evaluation of the excluded stomach after Roux-en-Y gastric bypass surgery for morbid obesity is a challenge, and the pathological changes that take place in the bypassed stomach are unclear. A new double-balloon method of evaluating the bypassed stomach after Roux-en-Y gastric

Central obesity in asymptomatic volunteers is associated with increased intrasphincteric acid reflux and lengthening of the cardiac mucosa.

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OBJECTIVE In the West, a substantial proportion of subjects with adenocarcinoma of the gastric cardia and gastroesophageal junction have no history of reflux. We studied the gastroesophageal junction in asymptomatic volunteers with normal and large waist circumferences (WCs) to determine if central

Short- and long-term changes in gastric morphology and histopathology following sleeve gastrectomy in diet-induced obese rats.

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BACKGROUND Sleeve gastrectomy (SG) has been used as a multipurpose surgical procedure for the treatment of morbid obesity. The aim of the study was to analyze gastric morphology and histology at two different time points after SG in rats. METHODS Thirty-five male Wistar rats were fed ad libitum

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