nicotinamide/inflammation

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Compositions and use of benzamides and nicotinamides as anti-inflammatory agents

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BACKGROUND OF THE INVENTION This invention relates to the use of benzamides and nicotinamides, and analogs of this class of compounds such as the N-substituted benzamides and nicotinamides, as anti-inflammatory agents, and to compositions for such use. The benzamide and nicotinamide analogs are

Substituted nicotinamide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease

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FIELD AND BACKGROUND The present invention relates to chemical compounds, pharmaceutical compositions including these compounds, and their use in treatment of disease. In particular, the present invention relates to the use of substituted nicotinimides as irreversible inhibitors of tyrosine kinases

Nicotinamide derivatives useful as PDE4 inhibitors

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This invention relates to nicotinamide derivatives of general formula: ##STR00001## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, and Z have the meanings indicated below, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of,

Nicotinamide derivatives useful as PDE4 inhibitors

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This invention relates to nicotinamide derivatives of general formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, and Z have the meanings indicated below, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of, such

Nicotinamide derivatives useful as PDE4 inhibitors

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This invention relates to nicotinamide derivatives of general formula: ##STR1## in which R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, n and m have the meanings indicated below, and to processes for the preparation of, intermediates used in the preparation of, compositions containing and the uses of,

Nicotinamide compounds useful as kinase modulators

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This application is a 371 of International Application No. PCT/US2010/038079, filed on Jun. 10, 2010, which claims benefit of U.S. 61/186,417, filed on Jun. 12, 2009. The present invention generally relates nicotinamide compounds useful as kinase modulators, including the modulation of Bruton's

Method and compositions for treating chronic inflammatory disorders

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TECHNICAL FIELD The present invention relates to an immune-modulating dietary supplement for treating chronic disorders, such as psoriasis, rheumatoid arthritis, inflammatory bowel disease and uveitis. BACKGROUND OF THE INVENTION Inflammation is part of the body's attempt at self-protection, and

Acetylenic compounds useful in treating inflammatory disorders

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STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT The research and development of the invention described below was not federally sponsored. BACKGROUND OF THE INVENTION This invention relates to a series of acetylenic compounds, pharmaceutical compositions and methods for use thereof.

Substituted heteroaryl and heterocyclic compounds useful in treating inflammatory disorders

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FIELD OF THE INVENTION This invention relates to a series of substituted heteroaryl and heterocyclic compounds, pharmaceutical compositions and methods for use thereof in treating or ameliorating an inflammatory disorder. More particularly, the substituted heteroaryl and heterocyclic compounds of

Use of vitamin combination for the treatment of pruritus and non-infective disorders involving itching and/or inflammation

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The present invention concerns the use of a vitamin combination for the treatment of pruritus and non-infective disorders involving itching and/or inflammation. More particularly, this invention relates to the use of a combination of two vitamin compounds, i.e. riboflavin (also known as vitamin

Use of a vitamin combination for the treatment of pruritus and non-infective disorders involving itching and/or inflammation

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SPECIFICATION The present invention concerns the use of a vitamin combination for the treatment of pruritus and non-infective disorders involving itching and/or inflammation. More particularly, this invention relates to the use of a combination of two vitamin compounds, i.e. riboflavin (also known

Oral composition and method for the treatment of inflammatory cutaneous disorders

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BACKGROUND OF THE INVENTION This invention relates to the use of a unique oral preparation for the treatment of inflammatory skin conditions. More particularly, this invention relates to a composition and method for the treatment of inflammatory skin conditions such as acne rosacea and acne vulgaris

Extracellular NAD.sup.+ and cADPR as potent anti-inflammatory agents

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CROSS REFERENCE TO RELATED APPLICATIONS N/A BACKGROUND OF THE INVENTION A necessary function of the intestinal epithelium is the establishment of a selective barrier to allow the absorption of nutrients while restricting the uptake of toxic substances and microbes from the gut lumen. A major

Nicotinamide derivatives

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BACKGROUND OF THE INVENTION This invention relates to nicotinamide derivatives that are selective inhibitors of phosphodiesterase type 4 (PDE4) and the production of tumor necrosins factor (TNF), and as such are useful in the treatment of respiratory, allergic, rheumatoid, body weight regulation,

Heteroaryl substituted nicotinamide compounds

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DESCRIPTION The present invention generally relates to heteroaryl substituted nicotinamide compounds useful as kinase inhibitors, including the modulation of IRAK-4. Provided herein are heteroaryl substituted nicotinamide compounds, compositions comprising such compounds, and methods of their use.

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