nicotinamide/kansè

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Nicotinamide N-methyltransferase as a marker for colorectal cancer

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FIELD OF THE INVENTION The present invention relates to the diagnosis of colorectal cancer. It discloses the use of nicotinamide N-methyltransferase (NNMT) in the diagnosis of colorectal cancer. Furthermore, it especially relates to a method for diagnosis of colorectal cancer from a liquid sample

Substituted nicotinamide inhibitors of BTK and their preparation and use in the treatment of cancer, inflammation and autoimmune disease

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FIELD AND BACKGROUND The present invention relates to chemical compounds, pharmaceutical compositions including these compounds, and their use in treatment of disease. In particular, the present invention relates to the use of substituted nicotinimides as irreversible inhibitors of tyrosine kinases

C-nucleoside isostere of nicotinamide adenine dinucleotide, analogs thereof and use as anti-cancer agent

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BACKGROUND OF THE INVENTION Throughout this application, various publications are referenced in Arabic numerals in parentheses. Full text citations of these publications can be found at the end of the specification, immediately preceding the claims. The disclosures of these publications in their

Use of aryl N-substituted carboxamides directly and as radio-and chemosensitizers for killing tumor and cancer cells and novel compounds for such use

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BACKGROUND OF THE INVENTION This invention relates to methods of inhibiting or killing tumor and cancer cells in human patients using aryl N-substituted carboxamides such as N-substituted benzamides and nicotinamides as direct chemotherapeutic agents or as sensitizers for radiation and/or other

Benzamide and nicotinamide radiosensitizers

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TECHNICAL FIELD The invention is in the field of radiotherapy. Specifically, it relates to sensitizing tumor cells to radiation using substituted benzamides. BACKGROUND ART Hypoxic tumor cell radiosensitizers are compounds that selectively increase the sensitivity of hypoxic cells in tumors to

Nicotinamide riboside kinase compositions and methods for using the same

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This application claims benefit of priority to PCT/US2006/015495, filed Apr. 20, 2006, which claims benefit from U.S. patent application Ser. No. 11/113,701, filed Apr. 25, 2005, now abandoned which is a continuation-in-part of PCT application No. PCT/US2005/004337, filed Feb. 9, 2005, which claims

Nicotinamide riboside kinase compositions and methods for using the same

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BACKGROUND OF THE INVENTION Nicotinic acid and nicotinamide, collectively niacins, are the vitamin forms of nicotinamide adenine dinucleotide (NAD+). Eukaryotes can synthesize NAD+ de novo via the kynurenine pathway from tryptophan (Krehl, et al. (1945) Science 101:489-490; Schutz and Feigelson

Benzamide and nicotinamide compounds and methods of using same

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BACKGROUND OF THE DISCLOSURE Cancer continues to be a major health problem in the United States and world-wide. In 2014, in the United States, there are expected to be more than 1.5 million new cancer cases and more than 580,000 cancer deaths. Cancer-related deaths account for nearly 1/4 of all

Benzamide and nicotinamide compounds and methods of using same

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Form A of mesylate for nicotinamide derivatives and preparation method and application thereof

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TECHNICAL FIELD The present invention relates to a molecular targeted antitumor drug, in particular to a form A of mesylate for nicotinamide derivatives, which is named Form A, and preparation method and application thereof. BACKGROUND ART Nicotinamide derivative (Aptinib), with a molecular formula

Nicotinamide phosphoribosyltransferase (NMPRTase) inhibitor for glioma therapy

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FIELD OF THE INVENTION The present invention relates to a method for identification of a compound which inhibits both the enzyme NMPRTase and glioma cancer cell growth, and therefore could be used for glioma therapy. More particularly, the present invention relates to the treatment of

Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl tranferase inhibitor

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2. FIELD OF THE INVENTION The present invention relates to methods and compositions useful for effecting NAD.sup.+ levels in a patient or a cell, and to methods and compositions useful in treating cancer deficient in nicotinic pathway. 3. BACKGROUND OF THE INVENTION Cancer is second only to

Pharmaceutical composition for the management of tumors

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FIELD OF INVENTION The present invention relates to a pharmaceutical composition for the management of tumors. More particularly, the present invention relates to concomitant use of naturally occurring compounds for the management of tumors. In general, the present invention relates to the complete

Uses of nicotinamide adenine dinucleotide and its derivatives for treatment of malignant and infectious diseases

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BACKGROUND OF THE INVENTION NAD and NADP are naturally occurring energy sources in cells. They are important cofactors to numerous enzymatic reactions. They are also substrates for NAD(P)ases which catalytically break down these products into nicotinamide and ADP-ribose or ADP-ribose phosphate. In

Substituted amides for treating and preventing cancer

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FIELD OF THE INVENTION This invention is in the field of medicinal chemistry. In particular, the invention relates to novel small molecule compounds having a quinolin-8-yl-nicotinamide structure which are useful in treating, ameliorating, or preventing various forms of cancer (e.g., pancreatic

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