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phospholipase d/gin diare
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TNF-alpha potentiates the ion secretion induced by muscarinic receptor activation in HT29cl.19A cells.
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Chronic gastrointestinal diseases such as ulcerative colitis and Crohn's disease are characterized by severe diarrhea. Mucosal biopsies of these patients show enhanced levels of cytokines, secreted by infiltrated inflammatory cells. In this study, we investigated the effect of the cytokine tumor
The B subunits of Shiga-like toxins induce regulated VWF secretion in a phospholipase D1-dependent manner.
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Shiga toxin (Stx) causes diarrhea-associated hemolytic uremic syndrome by damaging renal microvascular endothelium. The pentameric B subunits of Stx types 1 and 2 (Stx1B and Stx2B) are sufficient to stimulate acute VWF secretion from endothelial cells, but Stx1B and Stx2B exert distinct effects on
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