purine/atrophy

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Metabolomics: A Novel Tool for Investigating the Pathogenesis of Age-related Macular Degeneration

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Age-related macular degeneration (AMD) is the leading cause of adult blindness in developed countries and the third cause of global blindness. It is an eye-ageing disease with tremendous impact in daily quality of life. Clinically, AMD is a progressive disease, which evolves from early to late

Inosine 5'-Monophosphate to Raise of Serum Uric Acid Level in Patients With Multiple System Atrophy: a Multi-center, Randomized Controlled, Double Blind, Parallel Assigned Clinical Trial

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Background and objective: Uric acid (UA) is the end product of purine metabolism in human body, which is converted from the precursor metabolite inosine and finally excreted via route of urine and gastrointestinal tract. A high level of UA, usually ≥ 7.0 mg/dL, may lead to development of gout,

Intrathecal Methotrexate for Progressive Multiple Sclerosis: An Open Label Single Arm Study

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Protocol Intrathecal Methotrexate for Progressive Multiple Sclerosis: An Open Label Single Arm Study Introduction Multiple sclerosis (MS) is characterized pathologically by demyelination, axonal loss, and glial scar formation. Clinically, most patients have a relapsing-remitting course of MS (RRMS)

Oxidative Damage and Antioxidant Mechanisms in COPD

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Introduction Lung is a particularly important organ because of its interface with the environment. The environmental pollutants and endogenous reactive oxygen metabolites from inflammatory cells exert substantial pathological effects on the lung cells [1]. Oxidative stress (OS) is a major factor

Aminophylline in Bradyasystolic Cardiac Arrest

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Out-of-hospital cardiac arrest treated by emergency medical services has an estimated incidence of 54.99 per 100,000 person years, which translates to some 155,000 episodes annually in the United States. Bradyasystole is the first recorded rhythm in up to 52 percent of cardiac arrests, and many

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