purine/inflammation

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N-substituted-(Dihydroxyboryl)alkyl purine, indole and pyrimidine derivatives, useful as inhibitors of inflammatory cytokines

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BACKGROUND OF THE INVENTION Tumor necrosis factor alpha (TNF-.alpha.), also known as cachectin, is a 17 kDa protein produced by neutrophils, activated lymphocytes, macrophages, NK cells, LAK cells, astrocytes, endothelial cells, smooth muscle cells, and some transformed cells. A large number of

Purine derivatives and suppressants for inflammatory diseases

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FIELD OF THE INVENTION This invention relates to novel purine derivatives and pharmaceutical compositions containing thereof. The pharmaceutical compositions containing novel purine derivatives of the present invention are useful as suppressants for inflammatory diseases (anti-inflammatory drugs),

Anti-inflammatory substituted 9H-8-oxo-pyrimido[2,1-f]purine-2,4-diones

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The present invention relates to substituted 9H-8-oxo-pyrimido[2,1-f]purine-2,4-diones and tautomers thereof. These compounds are useful as anti-inflammatory agents for treating inflammatory conditions such as arthritis, spondylitis, and tendonitis in mammals. In a composition of matter aspect, the

Anti-inflammatory and anti-allergic substituted-2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]-purine-4,8(1H,9H)-dio nes

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BACKGROUND OF INVENTION The present invention relates to substituted 2,3-dihydro-6-(hydroxy)pyrimido[2,1-f]purine-4,8(1H, 9H)-diones and tautomers thereof. These compounds are useful as anti-inflammatory agents for treating inflammatory conditions such as arthritis, spondylitis, and tendonitis in

Hydroxyalkylammonium-pyrimidines or purines and nucleoside derivatives, useful as inhibitors of inflammatory cytokines

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2,6-Di (substitutedamino) purine ribonucleoside analogues and administration to treat respiratory inflammation

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The present invention relates to therapeutically active 2,6-diaminopurine-.beta.-D-ribofuranuronamide derivatives, processes for the manufacture of said compounds, pharmaceutical formulations containing said compounds and the use of said compounds in chemotherapy. In particular, we have found a

Purine derivatives and medicinal use thereof

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FIELD OF THE INVENTION The present invention relates to novel purine derivatives or pharmaceutically acceptable salts thereof and their application as medicines. The medicine comprising a purine derivative or a pharmaceutically acceptable salt thereof of the present invention as an active ingredient

Purine Derivatives and methods of use thereof

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1. FIELD OF THE INVENTION The invention relates to Purine Derivatives; compositions comprising an effective amount of a Purine Derivative; and methods for treating or preventing an ischemic condition, reperfusion injury, a cellular proliferative disorder, a cardiovascular disease, a neurological

Purine derivatives

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BACKGROUND OF THE INVENTION This invention relates to purine derivatives, to processes for their preparation, to compositions containing them and to their use. More particularly, the present invention relates to the use of purine derivatives in the treatment of a variety of viral infections and

Purine derivatives and methods of use thereof

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Purine and imidazopyridine derivatives for immunosuppression

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FIELD OF THE INVENTION The invention relates to purine and imidazopyridine derivatives useful as immunosuppressants. BACKGROUND OF THE INVENTION Immunosuppression is an important clinical approach in treating autoimmune disease and in preventing organ and tissue rejection. The clinically available

Purine derivatives as modulators of TNF activity

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This application is the US national phase under 35 U.S.C. .sctn. 371 of international application PCT/EP2014/076843, filed Dec. 8, 2014, which claims priority to GB application 1321737.7, filed Dec. 9, 2013. The present invention relates to a class of fused imidazole derivatives, and to their use in

Substituted 6-(2-hydroxybenzylamino)purine derivatives, their use as medicaments and compositions containing these derivatives

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FIELD OF THE INVENTION This invention relates to novel substituted 6-(2-hydroxybenzylamino)purine derivatives, to their activity as polyspecific inhibitors of cyclin-dependent kinases 2, 5, 7, and 9 and to their use as medicaments. BACKGROUND ART The cyclin-dependent kinases (CDKs) are heterodimeric

6, 9-disubstituted purine derivatives and their use as cosmetics and cosmetic compositions

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TECHNICAL FIELD The invention relates to 6,9-disubstituted purine derivatives as well as their use as, or in, cosmetics and/or cosmetic preparations. BACKGROUND ART In recent years, 6-substituted aminopurines have assumed considerable biochemical significance. Some compounds of this type promote

8-substituted 2-(benzimidazolyl)purine derivatives for immunosuppression

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FIELD OF THE INVENTION The invention relates to 8-substituted 2-(benzimidazolyl)purine derivatives and 8-substituted 2-(imidazolo[4,5-c]pyridinyl)purine derivatives useful as immunosuppressants. BACKGROUND OF THE INVENTION Immunosuppression is an important clinical approach in treating autoimmune

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