purine/stroke

Lyen an sove nan clipboard la

Chwazi kalite sòt

Paj 1 soti nan 90 rezilta yo

The association between early neurological deterioration and whole blood purine concentration during acute stroke.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Early neurological deterioration (END) is common after stroke. Prediction could identify patients requiring additional monitoring and intervention. Purines, breakdown products of adenosine triphosphate which accumulate during acute hypoxia, may reflect the subclinical presence of

[Cerebrospinal fluid concentrations of creatinine and purine metabolites determined by high performance liquid chromatography: preliminary report on head injury and stroke patients].

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

A prospective high performance liquid chromatography (HPLC) study was performed in eighteen patients with head injury and stroke and four control volunteers to evaluate creatinine and purine metabolites concentration (adenosine, inosine, hypoxanthine, uric acid) in cerebrospinal fluid (CSF). The

Point-of-care measurements reveal release of purines into venous blood of stroke patients.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Stroke is a leading cause of death and disability. Here, we examine whether point-of-care measurement of the purines, adenosine, inosine and hypoxanthine, which are downstream metabolites of ATP, has potential to assist the diagnosis of stroke. In a prospective observational study, patients who were

Stroke in purine nucleoside phosphorylase deficiency.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

The first documented case of cerebrovascular disease occurring in a 13-year-old girl with purine nucleoside phosphorylase deficiency is reported. This patient, the oldest known survivor with purine nucleoside phosphorylase deficiency, had previously experienced multiple sequential neurologic

An assessment of the possible protective effect of allopurinol in acute stroke.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Allopurinol has been shown to have a protective effect on ischaemic tissue by the indirect prevention of excessive purine loss. This property was tested in the gerbil model of acute stroke. A total of 69 animals were pretreated with an intraperitoneal injection of either allopurinol (50 mg/kg) or

A novel purine analogue bearing nitrate ester prevents platelet activation by ROCK activity inhibition.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Natural purines like ATP, ADP and adenosine have crucial roles in platelet physiology. This knowledge has been significant in drug development and today ADP receptor antagonists are widely used for prevention of thrombotic events following myocardial infarction and ischaemic stroke. Recent studies

Identification of malignant brain edema after hemispheric stroke by PET-imaging and microdialysis.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Cerebral blood flow (CBF) and extent of irreversible tissue damage as well as the time course of extracellular concentration of amino acids, substrates of energy metabolism, and purine metabolites, intracranial pressure and tissue oxygen tension were assessed in 34 patients with large strokes

HPLC assay with UV detection for determination of RBC purine nucleotide concentrations and application for biomarker study in vivo.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

ATP and other purine nucleotides are important biomarkers for ischemia and may have considerable potential as targets for management of ischemic heart disease and stroke. The main objective of the study is to develop a rapid HPLC assay, which has adequate sensitivity and specificity for measuring

The clinical application of purine nucleosides as biomarkers of tissue Ischemia and hypoxia in humans in vivo.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

During periods of ischemia and hypoxia, intracellular adenosine triphosphate stores are rapidly depleted. Its metabolism results in release of purine nucleosides into the systemic circulation. While the potential of purine nucleosides as a biomarker of ischemia has long been recognized, this has

Administration of Uric Acid in the Emergency Treatment of Acute Ischemic Stroke.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Oxidative stress is one of the main mechanisms implicated in the pathophysiology of inflammatory and neurodegenerative diseases of the central nervous system (CNS). Uric acid (UA) is the end product of purine catabolism in humans, and it is the main endogenous antioxidant in blood. Low circulating

Astrocytes affect the profile of purines released from cultured cortical neurons.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Adenosine (ADO) is produced by cultured neurons and astrocytes, albeit by different pathways, during in vitro stroke models (Parkinson and Xiong [2004] J. Neurochem. 88:1305-1312). Expression of ecto-5' nucleotidase (e-N), the enzyme responsible for extracellular dephosphorylation of AMP to ADO, is

Purine uptake and release in rat C6 glioma cells: nucleoside transport and purine metabolism under ATP-depleting conditions.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Adenosine, through activation of membrane-bound receptors, has been reported to have neuroprotective properties during strokes or seizures. The role of astrocytes in regulating brain interstitial adenosine levels has not been clearly defined. We have determined the nucleoside transporters present in

Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Ischemic stroke is a leading cause of morbidity and mortality in the US; however, there currently exists only one effective acute pharmacological therapeutic intervention. Purinergic signaling has been shown to regulate vascular function and pathological processes, including inflammation and

Danger signals in stroke and their role on microglia activation after ischemia.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Ischemic stroke is a major cause of death. Besides the direct damage resulting from oxygen and glucose deprivation, sterile inflammation plays a pivotal role in increasing cellular death. Damaged-associated molecular patterns (DAMPs) are passively released from dying cells and activate the innate

Effect of AIT-082, a purine analog, on working memory in normal and aged mice.

Se sèlman itilizatè ki anrejistre yo ki ka tradwi atik yo

Because working memory is the primary type of memory which is disrupted by Alzheimer's disease and stroke and during aging, any therapeutic drug for these conditions should improve and/or restore working memory. The win-shift memory paradigm has been shown to be an excellent model of working memory.

Antre nan paj
facebook nou an

Herbal & Natural Medicine

Baz done ki pi konplè remèd fèy medsin te apiye nan syans

Travay nan 55 lang
Geri èrbal te apiye nan syans
Remèd fèy rekonesans pa imaj
Kat entèaktif GPS - tag zèb sou kote (vini byento)
Li piblikasyon syantifik ki gen rapò ak rechèch ou an
Search remèd fèy medsin pa efè yo
Izeganize enterè ou yo ak rete kanpe fè dat ak rechèch la nouvèl, esè klinik ak rive

Tape yon sentòm oswa yon maladi epi li sou remèd fèy ki ta ka ede, tape yon zèb ak wè maladi ak sentòm li itilize kont.
* Tout enfòmasyon baze sou rechèch syantifik pibliye