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Inhibitors of poly(ADP-ribose) synthetase and use thereof to treat NMDA neurotoxicity
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FIELD OF THE INVENTION
The invention relates to the use of inhibitors of poly(ADP-ribose) synthetase to prevent NMDA neurotoxicity.
BACKGROUND OF THE INVENTION
Nitric oxide (NO) is a messenger molecule that regulates macrophage killing of tumor cells and bacteria (C. F. Nathan and J. B. Hibbs, Jr.,
Amide substituted indazoles as poly(ADP-ribose)polymerase(PARP) inhibitors
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BACKGROUND OF THE INVENTION
The present invention relates to amide substituted indazoles which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl)transferase. The compounds of the present invention are useful as
Tricyclic derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP)
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The present invention relates to tricyclic derivatives which are inhibitors of the enzyme poly(ADP-ribose)polymerase (PARP), previously known as poly(ADP-ribose)synthase and poly(ADP-ribosyl)transferase. Compounds of the present invention are useful as mono-therapies in tumors with specific defects
Pyridinone and pyridazinone derivatives as inhibitors of poly (ADP-ribose) polymerase (PARP)
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PRIORITY CLAIM
This application is a .sctn.371 National Stage Application of PCT/GB2007/050295, filed on May 25, 2007, which claims priority from GB Provisional Application Serial Number 0610680.1, filed on May 31, 2006.
The present invention relates to pyridinone and pyridazinone derivatives which
Quinolin-4-one and 4-oxodihydrocinnoline derivatives as inhibitors of poly(ADP-ribose) polymerase (PARP)
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PRIORITY CLAIM
This application is a .sctn.371 National Stage Application of PCT/GB2008/050731, filed on Aug. 21, 2008, which claims priority from GB Provisional Application Serial Number 0716532.7, filed on Aug. 24, 2007.
The present invention relates to quinolin-4-one and 4-oxodihydrocinnoline
Pyrrolo[1,2-a] pyrazin-1(2H)-one and pyrrolo[1,2-d][1,2,4]triazin-1(2H)-one derivatives as inhibitors of poly(ADP-ribose)polymerase (PARP)
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PRIORITY CLAIM
This application is a .sctn.371 National Stage Application of PCT/GB2007/050300, filed on May 29, 2007, which claims priority from GB Provisional Application Serial Numbers 0707359.6, filed on Apr. 17, 2007, and 0610670.2, filed on May 31, 2006.
The present invention relates to
Genes encoding several poly(ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
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TECHNICAL FIELD
The present invention relates to poly(ADP-ribose) glycohydrolases (PARGs) and peptides having poly(ADP-ribose) glycohydrolase activity. In addition, the invention also relates to antibodies, including monoclonal antibodies and antibody fragments, that have specific interaction with
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
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TECHNICAL FIELD
The present invention relates to poly(ADP-ribose) glycohydrolases (PARGs) and peptides having poly(ADP-ribose) glycohydrolase activity. In addition, the invention also relates to antibodies, including monoclonal antibodies and antibody fragments, that have specific interaction with
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
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TECHNICAL FIELD
The present invention relates to poly(ADP-ribose) glycohydrolases (PARGs) and peptides having poly(ADP-ribose) glycohydrolase activity. In addition, the invention also relates to antibodies, including monoclonal antibodies and antibody fragments, that have specific interaction with
Genes encoding several poly(ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
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TECHNICAL FIELD
The present invention relates to poly(ADP-ribose) glycohydrolases (PARGs) and peptides having poly(ADP-ribose) glycohydrolase activity. In addition, the invention also relates to antibodies, including monoclonal antibodies and antibody fragments, that have specific interaction with
Genes encoding several poly (ADP-ribose) glycohydrolase (PARG) enzymes, the proteins and fragments thereof, and antibodies immunoreactive therewith
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TECHNICAL FIELD
The present invention relates to poly(ADP-ribose)glycohydrolases (PARGs) and peptides having poly(ADP-ribose) glycohydrolase activity. In addition, the invention also relates to antibodies, including monoclonal antibodies and antibody fragments, that have specific interaction with
Tricyclic inhibitors of poly(ADP-ribose) polymerases
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FIELD OF THE INVENTION
The invention pertains to compounds that inhibit poly(ADP-ribose) polymerases, thereby retarding the repair of damaged DNA strands, and to methods of preparing such compounds. The invention also relates to the use of such compounds in pharmaceutical compositions and
Tricyclic inhibitors of poly(ADP-ribose) polymerases
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FIELD OF THE INVENTION
The invention pertains to compounds that inhibit poly(ADP-ribose) polymerases, thereby retarding the repair of damage to DNA strands, and to methods of preparing such compounds. The invention also relates the use of such compounds in pharmaceutical compositions and therapeutic
Tricyclic inhibitors of poly(ADP-ribose) polymerases
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FIELD OF THE INVENTION
The invention pertains to compounds that inhibit poly(ADP-ribose) polymerases, thereby retarding the repair of damage to DNA strands, and to methods of preparing such compounds. The invention also relates the use of such compounds in pharmaceutical compositions and therapeutic
Tricyclic inhibitors of poly(ADP-ribose) polymerases
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FIELD OF THE INVENTION
The invention pertains to compounds that inhibit poly(ADP-ribose) polymerases, thereby retarding the repair of damage to DNA strands, and to methods of preparing such compounds. The invention also relates the use of such compounds in pharmaceutical compositions and therapeutic
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