sinusitis/glutathione

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No evidence for a correlation of glutathione S-tranferase polymorphisms and chronic rhinosinusitis.

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OBJECTIVE Cellular detoxification mechanisms are mandatory for cellular protection against oxidative stress and reactive oxygen species. One major group of antioxidative active enzymes involved in cellular detoxification are the Glutathione S-Transferases (GST). Multiple subtypes like GSTM1, GSTP1,

Antioxidant levels in the nasal mucosa of patients with chronic sinusitis and healthy controls.

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BACKGROUND Imbalances between oxidant formation and antioxidative defense are associated with the pathogenesis of several chronic inflammatory disorders of the respiratory tract. Therefore, a role of oxidative stress in chronic upper airway tract infections can be anticipated. OBJECTIVE To determine

Oxidative Stress and Low Glutathione in Common Ear, Nose, and Throat Conditions: A Systematic Review.

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Context • Oxidative stress and tissue-damaging, oxygen (O2)-related, free-radical formation is inherent in human metabolism, and the tissues of the ear, nose, and throat (ENT) have an increased exposure to injury from those substances. Because glutathione (GSH) is a major component in an antioxidant

Inhaled glutathione for the prevention of air pollution-related health effects: a brief review.

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Exposure to air pollution is associated with significant adverse health effects, such as cardiovascular disease and asthma. Most current research trends focus on quantifying illnesses or deaths attributable to air pollutants, but limited research has examined potential methods of preventing these

The potential role of amlodipine on experimentally induced bacterial rhinosinusitis.

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BACKGROUND Antibiotics are frequently used for the treatment of rhinosinusitis. Concerns have been raised regarding the adverse effects of antibiotics and growing resistance. The lack of development of new antibiotic compounds has increased the necessity for exploration of non-antibiotic compounds

The role of interleukin-12, and tissue antioxidants in chronic sinusitis.

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BACKGROUND The role of cytokines and reactive oxygen species formation in the pathogenesis of chronic sinusitis is still not fully understood. This work was designed to determine if patients with chronic sinusitis demonstrate altered levels of serum IL-12 and/or tissue antioxidants. METHODS Mucosal

The effects of methylprednisolone and cefazolin sodium on antioxidant status in experimentally induced maxillary sinusitis.

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CONCLUSIONS Sinusitis is accompanied by deteriorated antioxidant status, which can be alleviated with administration of cefazolin sodium or methylprednisolone. Steroids improve sinusitis when combined with antibiotics. OBJECTIVE To evaluate the antioxidant status in response to treatment of

Experimentally induced acute sinusitis and efficacy of vitamin A.

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CONCLUSIONS Although antibiotics are the mainstays for treatment of sinusitis, they do not specifically treat tissue damage due to free radicals. We propose that antioxidant, anti-infective, immunomodulator vitamin A may be a useful addition in the management of sinusitis. OBJECTIVE Acute sinusitis

Lipid peroxidation and antioxidant enzyme activities in experimental maxillary sinusitis.

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The aims of this study were to assess whether th e increased oxidative stress of acute maxillary sinusitis is reflected by tissue lipid peroxidation and whether the activities of selected antioxidant enzymes are altered during inflammation of the maxillary sinus mucosa. Unilateral rhinosinusitis was

Safety survey of intranasal glutathione.

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OBJECTIVE Glutathione depletion has been documented in several disease states, and exogenous administration has been hypothesized to have therapeutic potential for some conditions. In an effort to reach target tissues of the sinuses and central nervous system (CNS), glutathione is being prescribed

Reactive Oxygen Species Are Necessary for Bleomycin A5-Induced Apoptosis and Extracellular Matrix Elimination of Nasal Polyp-Derived Fibroblasts.

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UNASSIGNED The pathology of chronic rhinosinusitis with nasal polyp (CRSwNP) is characterized by the infiltration of a large number of fibroblasts, resulting in extracellular matrix (ECM) deposition. Intralesional bleomycin A5 (BLE) injection has proved to be effective and safe, providing a novel

Antioxidant, antinociceptive, and anti-inflammatory activities of Xanthii Fructus extract.

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BACKGROUND Xanthii seeds commonly called Cang-Erzi were used as a traditional Chinese medicine for treating sinusitis, headache due to rheumatism and skin pruritus. OBJECTIVE In order to evaluate the actions of this plant, studies were performed on antioxidant, antinociceptive, and anti-inflammatory

The cigarette smoke component acrolein inhibits expression of the innate immune components IL-8 and human beta-defensin 2 by sinonasal epithelial cells.

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BACKGROUND Tobacco use is associated with poorer outcomes of medical and surgical therapy for chronic rhinosinusitis (CRS), although the underlying mechanism is unknown. Acrolein (AC) is a major component of cigarette smoke that has been shown to suppress innate immune gene expression by human

Investigation of biochemical and histopathological effects of Mentha piperita L. and Mentha spicata L. on kidney tissue in rats.

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Peppermint plants have been used as a herbal medicine for many conditions, including loss of appetite, common cold, bronchitis, sinusitis, fever, nausea, vomiting and indigestion. This study is aimed at investigating the biochemical and histological effects of Mentha piperita L., growing in the

Investigation of biochemical and histopathological effects of Mentha piperita Labiatae and Mentha spicata Labiatae on liver tissue in rats.

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The plant Mentha piperita, or peppermint, is commonly used in the treatment of loss of appetite, common cold, bronchitis, sinusitis, fever, nausea and vomiting, and indigestion as a herbal agent. In this study, we aimed to investigate biochemical and histological effects of M. piperita Labiatae,

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