Dyslipidemia

Diabetes

Prediabetes

Dysglycemia

Gout

Hypertension

Non-alcoholic Fatty Liver Disease

Cardiovascular Disease

An intervention in which calories from fructose-containing sugars are substituted, added, or subtracted in the diet

Fructose-containing Sugars

The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Michael's Hospital

Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors

Effect of Important Food Sources of Fructose-containing Sugars on Cardiometabolic Risk Factors: A Series of Systematic Reviews and Meta-analyses of Controlled Trials to Inform Dietary Guidelines, Public Health Policy, and Future Trial Design

glycated blood proteins, fasting blood glucose, fasting blood insulin

LDL-cholesterol, apol B, non-HDL-cholesterol, HDL-cholesterol, triglycerides

Intrahepatocellular lipid concentrations (IHCL), ALT

John Sievenpiper

Associate Professor

University of Toronto

Canadian Diabetes Association

The Physicians' Services Incorporated Foundation

Banting & Best Diabetes Centre

Body Weight

Obesity

Overweight

Adiposity

Obesity, Abdominal

An intervention in which calories from food sources of fructose-containing sugars are substituted, added, subtracted, or replaced ad libitum in the diet

Meta-analyses of Food Sources of Fructose-Containing Sugars and Obesity

Important Food Sources of Fructose-Containing Sugars and Markers of Adiposity and Risk of Obesity: A Series of Systematic Reviews and Meta-Analyses of Controlled Trials and Prospective Cohort Studies

American Society for Nutrition

Metabolic Syndrome

Oral dietary fructose in free (unbound) form in isocaloric exchange for other non-fructose carbohydrate sources (isocaloric trials) or added to a control diet as a source of excess energy (hypercaloric trials).

Dietary fructose

The Toronto 3D (Diet, Digestive tract and Disease) Knowledge Synthesis and Clinical Trials Unit, Clinical Nutrition and Risk Factor Modification Centre, St. Micheal's Hospital

Meta-analyses of Fructose and Cardiometabolic Risk

Effect of Fructose on Metabolic Control in Humans: A Series of Systematic Reviews and Meta-analyses to Provide Evidence-based Guidance for Nutrition Guidelines Development

Analyses:
Fasting lipids (triglycerides, HDL-cholesterol [C], LDL-C, apo-B, total-C:HDL-C ratio, apo-B:apo-A1 ratio, non-HDL-C)
Postprandial lipids (peak, mean, and area under the curve [AUC] triglycerides)

Analyses:
Glycated blood proteins (HbA1c, fructosamine, glycated albumin), glucose, and insulin in people with diabetes
Glycated blood proteins (HbA1c, fructosamine, glycated albumin), glucose, and insulin in people without diabetes
Insulin sensitivity (Euglycemic-hyperinsulinemic clamp, frequent sampling intravenous glucose tolerance test [FSIGT], Homeostasis model assessment of insulin resistance [HOMA-IR], oral glucose tolerance test insulin sensitivity index [OGTT-ISI])

Analyses:
1. Systolic BP, diastolic BP, and mean arterial pressure (MAP)

Analyses:
1. Lipids, glycemic control, body weight, blood pressure, and uric acid

Analyses:
1. Imaging and spectroscopy endpoints of liver fat (Liver ultrasound [US], computed tomography [CT], magnetic resonance imaging [MRI], or magnetic resonance spectroscopy [MRS]) and biomarkers of hepatocellular injury (transaminases [ALT, AST, GGT])

Adjunct Research Fellow

Canadian Institutes of Health Research (CIHR)

Canada Research Chairs Endowment of the Federal Government of Canada

Calorie Control Council

Abdominal Obesity

High Fructose Corn Syrup

Sucromalt

Glycemic Index Laboratories

Effect of Replacing HFCS With Sucromalt in Subjects With Raised Waist Circumference

Effect of Replacing HFCS With Sucromalt on Glucose Tolerance, Blood Lipids and Inflammatory Markers in Subjects With Raised Waist Circumference

starch

mayi

zea mays

starch/mayi

Meta-analyses of the Effect of Important Food Sources of Sugars on Cardiometabolic Risk Factors

Meta-analyses of Food Sources of Fructose-Containing Sugars and Obesity

Meta-analyses of Fructose and Cardiometabolic Risk

Effect of Replacing HFCS With Sucromalt in Subjects With Raised Waist Circumference

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