terpenoid/seizures

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Evaluation of the anticonvulsant activity of the seed acetone extract of Ferula gummosa Boiss. against seizures induced by pentylenetetrazole and electroconvulsive shock in mice.

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Ferula gummosa Boiss. (Apiaceae) which has been used as an antiepileptic remedy in Iranian traditional medicine was evaluated for anticonvulsant activity against experimental seizures. The seed acetone extract of F. gummosa protected mice against tonic convulsions induced by maximal electroshock

Anticonvulsant Activity of Teucrium polium Against Seizure Induced by PTZ and MES in Mice.

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Teucrium polium (Labiatae) is a plant that widely grows in Iran. Some of species of Teucrium are used for a considerable range of actions in traditional medicine and T. polium has frequently been used as anticonvulsant. In this study, we investigated the protective effects of T. polium ethanolic

Natural terpenoids as a promising source for modulation of GABAergic system and treatment of neurological diseases.

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γ-Aminobutyric acid (GABA) is the main inhibitory neurotransmitter reducing neural excitability in the mammalian central nervous system (CNS) with three subclasses of receptors. Several conventional drugs and compounds modulate the GABAergic system, demonstrating different pharmacological effects.

Quorum sensing inhibitory potential and in silico molecular docking of flavonoids and novel terpenoids from Senegalia nigrescens.

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BACKGROUND Senegalia nigrescens is used in traditional medicine for the treatment of dysentery and convulsions. OBJECTIVE This study was aimed at identifying bioactive compounds from S. nigrescens and carrying out in vitro and in silico anti-quorum sensing studies on the compounds. METHODS Extracts

Antinociceptive and Antioxidant Activities of the Methanolic Extract of Telfairia occidentalis Seeds.

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BACKGROUND The seeds of Telfairia occidentalis have been known to possess different biological properties and are used in traditional medicine in Africa and Asia to treat many ailments. The plant is particularly noted traditionally for its healing properties and is usually consumed in the form of

Anticonvulsant activity of Heracleum persicum seed.

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The anticonvulsant activity of acetone extract of the seeds of Heracleum persicum (Umbelliferae) was examined against pentylenetetrazole (PTZ) and maximal electroshock (MES)-induced seizures in mice. The extract showed a dose-dependent protective effect in both seizure models. However, the sedative

Phytochemistry and neuroprotective effects of Eclipta alba (L.) Hassk.

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Eclipta alba (L.) Hassk. or Eclipta prostrata (Linn.) or Eclipta erecta (Linn.) is an herbaceous plant well known in Asian as African traditional medicines. These extracts are used in traditional medicine for treatment of microbial diseases and certain metabolic disorders. This review aimed to

The role of polar phytocomplexes on anticonvulsant effects of leaf extracts of Lippia alba (Mill.) N.E. Brown chemotypes.

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OBJECTIVE The purpose of the present work was to characterize the pharmacological profile of different L. alba chemotypes and to correlate the obtained data to the presence of chemical constituents detected by phytochemical analysis. METHODS Essential oils from each L. alba chemotype (LP1-LP7) were

Ursolic acid plays a role in Nepeta sibthorpii Bentham CNS depressing effects.

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The sedative, anticonvulsant and analgesic activity of ursolic acid, a terpenoid bioassay-isolated from Nepeta sibthorpii Bentham, was evaluated in mice. The oral administration of ursolic acid (2.3 mg/kg) produced a significant depressant effect on CNS by reducing spontaneous motor activity and the

The current status of artisanal cannabis for the treatment of epilepsy in the United States.

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The widespread patient use of artisanal cannabis preparations has preceded quality validation of cannabis use for epilepsy. Neurologists and cannabinoid specialists are increasingly in a position to monitor and guide the use of herbal cannabis in epilepsy patients. We report the retrospective data

Effects of woohwangcheongsimwon suspension on the pharmacokinetics of bupropion and its active metabolite, 4-hydroxybupropion, in healthy subjects.

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BACKGROUND Woohwangcheongsimwon suspension has traditionally been used for the treatment and prevention of stroke, hypertension, palpitations, convulsions and unconsciousness in various Asian countries. Woohwangcheongsimwon suspensions showed an inhibitory effect on CYP2B6 activity in vitro. Two

Anticonvulsant and anxiolytic activity of the leaf aqueous and ethanolic extracts of Melanthera scandens in a rat model.

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Modern drug therapy of epilepsy is complicated by the inability of drugs to control seizures in some patients and side effects that range in severity from minimal impairment of the central nervous system to death from aplastic anemia or hepatic failure. Medicinal plants used in traditional medicine

Novel (‒)-carvone derivatives as potential anticonvulsant and analgesic agents.

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Novel hydrazones based on (‒)-carvone were synthesized via condensation of terpenoid with 4-R-phenoxyacetic acid hydrazides. The structure of target compounds was established by FT-IR, Raman, ¹H-NMR and ¹³C-NMR spectral analysis, FAB/ESI mass spectrometry. (‒)-Carvone

Non-clinical toxicity of (+)-limonene epoxide and its physio-pharmacological properties on neurological disorders

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The compound (+)-limonene epoxide has antioxidant, anxiolytic, and antihelminthic properties. However, investigations to determine its long-term exposure were not performed. We investigated the systemic toxicological profile after chronic exposure as well as the antidepressant and antiepileptic

Effects of Jasminum multiflorum leaf extract on rodent models of epilepsy, motor coordination and anxiety.

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Jasmine flowers and leaves are used extensively in folk medicine in different parts of the world to treat a variety of diseases. However, there are very few published reports on the neuropsychiatric effects of Jasmine extracts. Hence, the objectives of the present study were to examine the effects

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