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BACKGROUND
In vitro, animal and epidemiological studies suggest that lipoprotein oxidation may play an important role in atherosclerosis. Antioxidants may protect against lipoprotein oxidation and in that way inhibit atherosclerosis and its clinical sequelae. To investigate this possibility, we
OBJECTIVE
Epidemiologic studies have suggested that dietary intake and plasma concentrations of antioxidants have an inverse relation with coronary heart disease. To test whether fat-soluble antioxidants can play a role against the occurrence of myocardial infarction (MI), we measured plasma levels
Lipid peroxidation in rat liver tissue homogenate was studied by evaluation of diene conjugates and Schiff bases content within 24 hrs after myocardium infarction. Tocopherol was estimated using spectrofluorimetric procedure. Ionol was administered intraperitoneally at a dose of 120 mg/kg within 15
OBJECTIVE
We investigated whether dietary supplementation with the antioxidant vitamin alpha-tocopherol (500 mg daily) might reduce lethal ventricular arrhythmias and infarct size.
BACKGROUND
Previous studies suggested that dietary supplementation with alpha-tocopherol may be associated with a
The alpha-tocopherol analogue 3,4-dihydro-6-hydroxy-N,N,N,2,5,7,8- heptamethyl-2H-1-benzopyran-2-ethanaminium 4-methylbenzenesulfonate (1a, MDL 73404) and its O-acetate 1b (MDL 74270) were synthesized. Compound 1a was found to be hydrophilic (log P = -0.60) and to prevent lipid autoxidation in rat
A course-wise administration of sodium selenate (30 gamma/kg), alpha-tocopherol (50 mg/kg) and of their combination in the same doses brings down the catecholamines content in the heart and suprarenals in the acute period of developing myocardial infarction (2nd day) with its subsequent
BACKGROUND
Gamma-tocopherol, the most abundant form of dietary vitamin E, may lower the risk of coronary heart disease.
METHODS
We investigated whether dietary and adipose tissue gamma-tocopherol are associated with myocardial infarction (MI) in 475 survivors of a first MI and 479 controls from a
Thirty patients of acute myocardial infarction proven by electrocardiography (ECG) and enzymes were included in the study. All of them received streptokinase. A single lead showing the largest ST elevation, a proportional value for the shift in ST segment > or = 0.5 was taken as criteria for
The present study was designed to evaluate the effects of pretreatment with antioxidants on free radical mediated reprefusion injury. Five dogs were fed with alpha-tocopherol (1000 IU/kg, bw) for ten days prior to 90 min of left anterior descending coronary artery occlusion followed by 4 hours of
Alpha-tocopherol and its derivatives have been shown to be effective in reducing cerebral ischemia-induced brain damage. However, the effects of other vitamin E isoforms have not been characterized. In the present study, we investigated the effects of six different isoforms of vitamin E on the
Observation of groups of patients receiving traditional treatment and alpha-tocopherol indicates that inclusion of this agent in the treatment of patients suffering of myocardial infarction produced a favourable effect on normalization of the reduced stroke volume of the heart and increased
A new non-injection method was used to study the quantitative values characterizing the condition of the microcirculatory channel of the peri-infarct zones of rat myocardium without treatment and in treatment with nitroglycerin, alpha-tocopherol, and sodium nucleinate. In combined administration of
A low serum tocopherol concentration and a low proportion of linoleic acid in plasma cholesterol esters have been reported to be associated with coronary heart disease. This study was undertaken to evaluate the predictive importance of the serum cholesterol ester fatty acid composition and serum
It is shown that combined administrations of alpha-tocopherol and sodium nucleinate lead to normalization of qualitative and quantitative content of phospholipids in the myocardium of rabbits under conditions of an experimental myocardial infarction. The changes obtained are accompanied by a
The effect of alpha-tocopherol pretreatment (6 mg/100 g body wt/day, orally for a period of 90 days) on mitochondrial electron transport in myocardial infarction induced by isoproterenol (20 mg/100 g body wt, subcutaneously for two days) was studied in rats. A significant decrease was observed in