A fungal wild-type lipolytic enzyme having a higher ratio of activity on polar lipids compared with triglycerides, wherein the enzyme preferably has a phospholipid:triglyceride activity ratio of at least 4. Preferably, the lipolytic enzyme according to the present invention has a glycolipid:triglyceride hydrolyzing activity ratio of at least 1.5. In one embodiment, the fungal lipolytic enzyme according to the present invention comprises an amino acid sequence as shown in SEQ ID NO: 1 or SEQ ID No. 2 or SEQ ID No. 4 or SEQ ID No. 6 or an amino acid sequence which has at least 90% identity thereto. The present invention further encompasses a nucleic acid encoding a fungal lipolytic enzyme, which nucleic acid is selected from the group consisting of: (a) a nucleic acid comprising a nucleotide shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7; (b) a nucleic acid which is related to the nucleotide sequence of SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7 by the degeneration of the genetic code; and (c) nucleic acid comprising a nucleotide sequence which has at least 90% identity with the nucleotide sequence shown in SEQ ID No. 3, SEQ ID No. 5 or SEQ ID No. 7.

Danisco A/S

Fungal lypolytic and amylase enzyme composition and methods using the same

Fungal lipolytic enzymes, nucleic acids encoding, and uses thereof

This invention provides a highly concentrated licorice polyphenol preparation with high bioavailability. Further, this invention is intended to maintain high transparency of a composition without deterioration of the indigenous properties of an aqueous substance, even when such composition is added thereto. Such licorice polyphenol preparation comprises a hydrophobic licorice extract comprising licorice polyphenol as a primary component, medium-chain fatty acid triglyceride, and polyoxyethylene sorbitan fatty acid ester, and the ratio of the total weight of the hydrophobic licorice extract and medium-chain fatty acid triglyceride to the weight of polyoxyethylene sorbitan fatty acid ester is between 1:1 and 1:10.

Sakai; Midori

Ikehara; Toshinori

Kaneka Corporation

Licorice polyphenol preparation

The present invention provides a method for treating type 1 diabetes, hyperlipidemia or hepatic lipid accumulation by using dehydroeburicoic acid, as well as a method for decreasing levels of blood glucose, plasma total cholesterol, and triglyceride, and increasing insulin levels; and a method for decreasing hepatic balloon degeneration; and increasing expression levels of membrane GLUT4 and phospho-Akt in myotubes; and enhancing expression levels of membrane glucose transporter 4 (GLUT4) in skeletal muscle, and phospho-AMPK in both skeletal muscle and liver tissue using dehydroeburicoic acid.

Shih; Chung-Ching

Shih; Chun-Ching

Use of dehydroeburicoic acid from Antrodia camphorata in the treatment or prevention of diabetes and hyperlipidemia

triglyceride

atrophy

triglyceride/atrophy

Fungal lypolytic and amylase enzyme composition and methods using the same

Fungal lipolytic enzymes, nucleic acids encoding, and uses thereof

Licorice polyphenol preparation

Use of dehydroeburicoic acid from Antrodia camphorata in the treatment or prevention of diabetes and hyperlipidemia

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