Evaluation of the anti-depressant activity of Myristica fragrans (Nutmeg) in male rats.
Kulcsszavak
Absztrakt
OBJECTIVE
The present study was undertaken to evaluate anti-depressant activity of Myristica fragrans (MS).
METHODS
Male Wistar rats were subjected to imipramine and herbal extract of MS for their antidepressant activity using Forced Swimming Test (FST), Reserpine Reversal Test (RRT), Haloperidol-Induced Catalepsy (HIC), and Pentobarbitone Sleeping Time (PST).
RESULTS
Administration of MS and imipramine revealed a statistically significant reduction in immobility time in FST, RRT, and protection against HIC, compared to the control group. However, there was no significant potentiation of PST.
CONCLUSIONS
Our study demonstrated the potential antidepressant activity of MS.