[Experimental study on effect of altitude xishi capsule in treating oleic acid induced lung injury in acute hypoxia rats].

OBJECTIVE

To explore the effect and pathophysiological mechanism of Altitude Xishi Capsule (XSC) on lung injury during acute hypoxia.

METHODS

A new model of acute lung injury was established by administering oleic acid into superior vena cava in experimental rat during acute hypoxia, which was formed by putting the animal in a hypobaric room, and reduced the pressure gradually in uniform speed till a simulated environment of 6000 m above sea level was formed and lasted for 12 hours. XSC was given orally to the rat before oleic acid administration. The effect of XSC on the model was observed by determination of PaO2, wet/dry ratio of lung and pathologic examination at 1, 2, 3 and 4 hours separately.

RESULTS

The respiratory frequency of model animal increased markedly, with the water content of lung reduced and aggravated as the hypoxia prolonged. XSC could obviously improve the pulmonary edema and inflammatory cell infiltration in lung.

CONCLUSIONS

The aforesaid acute lung injury model with successful rate of 100%, it resembles the clinical acute lung injury and was useful for research on pathophysiology and treatment of ARDS or acute lung injury, XSC could improve the oleic acid induced lung injury in hypoxia rats by reducing the pulmonary edema and inflammatory cell infiltration.