. A case study was used to discuss the effects of traditional Chinese medicine (TCM) treatments on Sjögren's syndrome. CLINICAL FEATURES AND OUTCOMES: . A 45-year-old woman suffered from dry eyes, dry mouth, and fatigue for six months and was diagnosed with Sjögren's syndrome. She had received regular treatment with hydroxychloroquine (HCQ) and artificial tears as well as artificial saliva for nearly one year, but the results were unsatisfactory. Therefore, she sought CHM for further intervention. After 7 months of Yi-Guan-Jian with Huai-Xiao-Mai (Triticum aestivum Linn.) and Tian-Hua-Fen (Trichosanthis Radix), on the seventh treatment with TCM, she reported no fatigue or sleep dysfunction and relief of dry eyes and mouth. Neither complications nor side effects were noted during the CHM treatment.. From this case, we concluded that CHM may be an effective and safe alternative therapy for the treatment of Sjögren's syndrome.