Evaluation of chromium accumulation and resulting histopathological changes in Libyan jirds (Mammals, Rodentia), affected by effluent from Ghazghan leather industrial town, Iran

The leather industry is one of the major producers of wastewater, releasing large amounts of various chemicals into the environment. Chromium (Cr) is the most commonly used agent in the tanning industry. Accumulation in the animal body can adversely affect the functioning of animal tissues. The current study investigated the toxic effects of Cr on lung, kidney, liver, and testicular tissues in Libyan jirds (Meriones libycus) inhabiting the area surrounding Ghazghan leather industrial town, Mashhad, Iran. Average Cr concentrations were found to be significantly higher in samples from contaminated areas than controls (p < 0.05). The highest accumulation of Cr was found in lung tissue, while the liver tissue showed the lowest. The results also showed that sex and age had no significant effect on Cr accumulation in any tissue at either sampling area (p < 0.05). Histological analyses showed that Cr accumulation had caused changes in tissue samples from Libyan jirds from the contaminated area. Hyperemia was observed in all tissues. In kidney tissue, necrosis and degeneration of the epithelial cells of the tubules were seen as well, and in one case, we also observed hemorrhage. In liver tissue, necrosis, degeneration, and inflammation were observed, along with one case, of fibrosis. In lung tissue, we observed emphysema, hemorrhage, and inflammation. Testicular tissue also showed a considerable lesion. Given the proximity of specimens' habitat to an area of importance, i.e., the industrial town, and the species' dependence on its habitat for nutrition, Libyan jirds are particularly useful for monitoring. Thus, they can be used to monitor the level of contamination in future studies.

Keywords: Chromium; Histopathology; Leather industry; Small mammals; Tannery wastewater.