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Role of hypothalamic neuropeptide Y in feeding and obesity.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

The 36-amino-acid peptide, neuropeptide Y (NPY), is the most abundant peptide in the rat brain. When administered into the brain, NPY produces a variety of physiological actions including a pronounced stimulation of feeding in satiated rats. Elevations in hypothalamic NPY have been reported after

Hypothalamic neuropeptide Y messenger ribonucleic acid levels in pre-obese and genetically obese (fa/fa) rats; potential regulation thereof by corticotropin-releasing factor.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Neuropeptide Y (NPY) is a 36 amino-acid peptide. It is localized within the brain but is also present peripherally. It is a well substantiated orexigenic peptide with several other endocrine and behavioural effects. In this study NPY mRNA levels were measured, using the polymerase chain reaction

Direct plasma radioimmunoassay for rat amylin-(1-37): concentrations with acquired and genetic obesity.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Amylin (islet-associated polypeptide) is a 37-amino acid peptide that is cosecreted with insulin from the pancreatic beta-cell. Accurate measurement of its plasma levels is important for delineating the physiological range over which amylin acts. We describe a reproducible, highly specific, and

Recent advances in potential clinical application of ghrelin in obesity.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Ghrelin is the natural ligand of the growth hormone secretagogue receptor (GHS-R1a). Ghrelin is a 28 amino acid peptide possessing a unique acylation on the serine in position 3 catalyzed by ghrelin O-acyltransferase (GOAT). Ghrelin stimulates growth hormone secretion, but also appetite, food

Ghrelin--a novel generation of anti-obesity drug: design, pharmacomodulation and biological activity of ghrelin analogues.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Ghrelin is a unique bioactive peptide with respect to both the structure and its biological function. This 28-amino acid peptide is modified with an n-octanoyl group at serine-3, and accordingly is the only lipidated biologically active peptide hormone known so far. Ghrelin binds to the so-called

[Leptin and obesity].

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Obesity is associated with increased incidence of cardiovascular diseases, insulin resistance, dyslipoproteinemia and cancer. The discovery of leptin in 1994 has provided a lot of new information about obesity. Leptin is a 167-amino acid peptide synthetized almost exclusively in adipose tissue. This

Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Uroguanylin is a 16 amino acid peptide that constitutes a key component of the gut- brain axis with special relevance in body weight regulation. In childhood and adolescence, periods of life with notable metabolic changes; limited data exist, with measurements of pro-uroguanylin in adolescence but

Fasting Ghrelin Levels Are Decreased in Obese Subjects and Are Significantly Related With Insulin Resistance and Body Mass Index.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

BACKGROUND Ghrelin is a 28-amino acid peptide that predominantly produced by the stomach. Strong evidence indicates the effects of ghrelin in the regulation of metabolic functions and its potential role in the aetiology of obesity. OBJECTIVE The aim of this study was to investigate the relationship

Glucagon-like peptide-1 in the pathogenesis of obesity.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

The recently discovered gut peptide glucagon-like peptide-1 (GLP-1) is one of many peptides implicated in the short-term regulation of appetite. GLP-1 is a 30-amino-acid peptide that is produced in and secreted from the L cells of the intestinal mucosa after intake of a mixed meal. The amino acid

[ob protein--product of expressing an obesity gene and some aspects of modern-day endocrinology].

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

A brief review of the studies on the obese (ob) gene is given. The ob gene is a mouse gene, the mutations of which are associated with altered metabolism and increased lipid deposits in adipose tissue. Recessive ob gene mutations in homozygous mice result in obesity and diabetes mellitus. Both mouse

Tissue distribution and effects of fasting and obesity on the ghrelin axis in mice.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Ghrelin is a 28 amino acid peptide hormone derived from the 117 amino acid proghrelin, following cleavage by proprotein convertase 1 (PC1). In this study, we comprehensively assessed the tissue distribution and the effect of fasting and obesity on preproghrelin, Exon-4D, PC1 and GOAT expression and

Plasma cholecystokinin levels in Prader-Willi syndrome and obese subjects.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

The cardinal feature of individuals with Prader-Willi syndrome (PWS) is severe hyperphagia-mediated obesity resulting from a faulty satiety mechanism. PWS is the most common genetic cause of marked obesity. Cholecystokinin (CCK) is a 33-amino-acid peptide found in high levels in the gut and brain

Galanin-like peptide mRNA alterations in arcuate nucleus and neural lobe of streptozotocin-diabetic and obese zucker rats. Further evidence for leptin-dependent and independent regulation.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Galanin-like peptide (GALP) is a 60-amino-acid peptide with structural similarities to galanin and a high affinity for galanin receptors. GALP is expressed by a discrete population of neurons in the arcuate nucleus (ARC) and median eminence of the hypothalamus of several species, including the rat.

Marked GH secretion after ghrelin alone or combined with GH-releasing hormone (GHRH) in obese patients.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

OBJECTIVE Ghrelin is a 28-amino-acid peptide, predominantly produced by the stomach. It displays a strong GH-releasing activity mediated by the hypothalamus-pituitary GH secretagogue (GHS)-receptor (GHS-R). There are different studies that suggest the importance of ghrelin in feeding and weight

Effect of acute ghrelin administration on glycaemia and insulin levels in obese patients.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

OBJECTIVE Ghrelin is a 28-amino-acid peptide, predominantly produced by the stomach. There are several studies that suggest the importance of ghrelin in obesity. However, the pancreatic endocrine response to ghrelin in obesity is unclear at present. The aim of this study was to clarify whether

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