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[Intra-arterial chemotherapy with nor-adrenaline. Experimental study 1 (enhancement of anti-tumor effect and tumor vessels)].

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We have performed studies to observe whether the administration of nor-adrenaline during intraarterial chemotherapy has the possibility of increasing the permeability of tumor vessels and thus enhancing the anti-cancer effects. The tumor model was Walker-256, which was implanted into the dorsum side

Regulation of tumor necrosis factor production by adrenaline and beta-adrenergic agonists.

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The effects of adrenaline and isoproterenol, a specific beta-adrenergic agonist, on TNF production were investigated. Both agents inhibited the production of TNF by human blood and THP-1 cells stimulated by LPS. The effect of adrenaline was prevented by a beta-receptor antagonist, but not by an

[Distortion of the pressor response to adrenaline in hepatectomized and tumor-bearing rats].

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Similar distortion of hypertensive response to epinephrine occurred in sarcoma-45-bearing rats, Walker carcinosarcoma-bearing rats, and hepatectomized rats. The response in the last-named was distorted on the 3rd postoperative day. The hypertensive response to epinephrine was restored after the

Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment.

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BACKGROUND Pre-cancerous lesions of cervix (cervical intraepithelial neoplasia (CIN)) are usually treated with excisional or ablative procedures. In the UK, the NHS cervical screening guidelines suggest that over 80% of treatments should be performed in an outpatient setting (colposcopy clinics).

Pain relief for women with cervical intraepithelial neoplasia undergoing colposcopy treatment.

Csak regisztrált felhasználók fordíthatnak cikkeket

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BACKGROUND Pre-cancerous lesions of cervix (cervical intraepithelial neoplasia (CIN)) are usually treated with excisional or ablative procedures. In the UK, the National Health Service (NHS) cervical screening guidelines suggest that over 80% of treatments should be performed in an outpatient

Deuterium MR spectroscopy at 4.7 T. Quantification of tumour and subcutaneous tissue blood flow in animal models.

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Deuterium MR spectroscopy was used for the determination of tissue blood flow (TBF). The tracer D2O was injected into the tissue of interest, and tracer washout was followed using a 4.7 T spectroscopy/imaging unit. Normal subcutaneous tissue in rats was studied, as well as tissue influenced by

[Effect of hypolipidemic preparations on basal and stimulated adenylate cyclase activity in tumor cells].

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A study was made of the action of the antidiabetic biguanide phenformin, clofibrate and the phospholipid drug Essentiale on the basal and adrenaline-stimulated activity of adenylate cyclase in Ehrlich's ascites carcinoma cells. All the drugs under study potentiated the hormone-stimulated activity of

[Catecholamines in the cardiovascular expression of pheochromocytomas. I. Physiological role of noradrenaline, adrenaline and dopamine].

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The very diverse clinical expressions of pheochromocytoma are dependent upon type of catecholamine secreted and excreted by the tumor. The role of each of the three amines (adrenaline, noradrenaline, dopamine) is reviewed in relation to physiologic regulation of blood pressure: adrenaline and

Nicotine stimulates pancreatic cancer xenografts by systemic increase in stress neurotransmitters and suppression of the inhibitory neurotransmitter gamma-aminobutyric acid.

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Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer mortality in Western countries. We have shown previously that four representative human PDAC cell lines were regulated by beta-adrenoreceptors via cyclic adenosine 3',5'-monophosphate (cAMP)-dependent signaling. In the current

Pancreatic cancer cells and normal pancreatic duct epithelial cells express an autocrine catecholamine loop that is activated by nicotinic acetylcholine receptors α3, α5, and α7.

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Pancreatic cancer is the fourth leading cause of cancer deaths in developed countries. Smoking is an established risk factor for this malignancy but the underlying mechanisms are poorly understood. Previous reports have provided evidence that nicotinic acetylcholine receptors (nAChR) and beta

Lowering of innate resistance of the lungs to the growth of blood-borne cancer cells in states of topical and systemic stress.

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The survival and clonogenic growth (measured in terms of colony forming efficiency (CFE) of intravenously injected (i.v.) Walker (W256) tumour cells in the lungs of rats was greatly enhanced by states of topical and systemic stress induced by the intraperitoneal (i.p.) injection of rats with a

Gamma-amino butyric acid (GABA) prevents the induction of nicotinic receptor-regulated signaling by chronic ethanol in pancreatic cancer cells and normal duct epithelia.

Csak regisztrált felhasználók fordíthatnak cikkeket

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Pancreatic cancer has a high mortality rate and alcoholism is a risk factor independent of smoking. We have shown that nicotinic acetylcholine receptors (nAChR) regulate pancreatic ductal epithelia and pancreatic ductal adenocarcinoma (PDAC) cells in an autocrine fashion by stimulating their

Effects of catecholamines on cardiovascular response and blood flow distribution to normal tissue and liver tumors in rats.

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The effects of infusion of adrenaline and noradrenaline were studied in rats with intrahepatic tumors, using 99mTc-and 51Cr-labeled microspheres. The effect on general circulation, cardiac output, and tissue blood flow was pronounced, especially with infusion of noradrenaline. Studies of liver tumor

Regulation of tumour necrosis factor production by adrenal hormones in vivo: insights into the antiinflammatory activity of rolipram.

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1. The role of adrenal hormones in the regulation of the systemic and local production of tumour necrosis factor (TNF alpha) was examined in male Balb/c mice. 2. Intraperitoneal injection of 0.3 mg E. coli lipopolysaccharide (LPS, 0111:B4) led to high levels of circulating TNF alpha without

Hypotensive Epidural Anesthesia Reduces Blood Loss in Pelvic and Sacral Bone Tumor Resections.

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BACKGROUND Resection of pelvic and sacral tumors can cause severe blood loss, complications, and even postoperative death. Hypotensive epidural anesthesia has been used to mitigate blood loss after elective arthroplasty, but to our knowledge, it has not been studied as an approach that might make

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