We will recruit 30 poor ovarian responders and thin endometrium patients and treat with intravenous laser irradiation of blood (ILIB) via an intravenous catheter for irradiation of the blood under a period of 60 minutes for 10 days.

We will recruit 30 poor ovarian responders and thin endometrium patients and treat with oral estradiol 8 mg per day and oestrogen gel 4 g per day for 14 days

Endometrium

Laser

Intravenous laser irradiation treatment

Department of Obstetrics and Gynecology, Kaohsiung Veterans General Hospital

Intravenous Laser Irradiation Effect on Treatment Resistant Thin Endometrium

Effects of Intravenous Laser Irradiation on Treatment Resistant Thin Endometrium in Women Undergoing Frozen Thawed Embryo Transfer Cycles

endometrium thickness evaluated by transvaginal sonography after intervention

Hsiao-Wen Tsai

Dr. Hsiao-Wen Tsai

Kaohsiung Veterans General Hospital.

Patients with POF, POI or Low Ovarian Reserve choosing to enroll will be provided informed consent for Rejuvenation of Premature Ovarian Failure With Stem Cells (ROSE-1). They will undergo diagnosis and screening confirming diagnosis including History and Physical Exams, Labs and Diagnostic Procedures. Following final approval and under anesthesia, bone marrow aspiration with separation of the bone marrow derived stem cell fraction will be performed. Diagnostic laparoscopy will allow for assessment of pelvic anatomy and subsequent injection of the bone marrow derived stem cells into the right ovary.

Primary Ovarian Insufficiency

Low Ovarian Reserve

Premature Ovarian Failure

A bone marrow aspiration will be performed under anesthesia in preparation for a diagnostic laparoscopy for full evaluation of the pelvic anatomy. Following laparoscopy, injection of BMSCs into the right ovary will occur.

ROSE-1 Protocol

University of Illinois at Chicago

Rejuvenation of Premature Ovarian Failure With Stem Cells

Autologous Stem Cell Therapy for Premature Ovarian Insufficiency and Low Ovarian Reserve

Reduction of 50% in FSH values; increase in AMH and Estradiol levels (30%)

Resumption of menses. Improved quality of life using the North American Menopausal Society (NAMS) validated menopause health questionnaire.

Improvement in hormonal levels toward normal ranges. Hormones may include FSH/LH; Estradiol/ progesterone;Inhibin; Anti- Mullerian Hormone

Achievement of pregnancy by natural or assisted conception methods as may be deemed appropriate by the patient and her primary provider.

anti aging/infarktus

Intravenous Laser Irradiation Effect on Treatment Resistant Thin Endometrium

Rejuvenation of Premature Ovarian Failure With Stem Cells

A legteljesebb gyógynövény-adatbázis, amelyet a tudomány támogat