A composition for the treatment of skin injuries is described including an antiseptic, a sapogenine, a proteolytic enzyme and a suitable vehicle. The composition is directly applied on the injury, forming a film which isolates and protects same from infection and suppresses pain. The film is self-adherent and transparent, which allows inspection of the healing injury, without the need of removing the film, as with bandages. The composition is antiseptic and microbiocidal, helps cicatrization and produces a biochemical debridement. The film allows the natural motility of the injury zone and produces a compression which helps to decrease or prevent edema. The film also allows the passage of air, preventing the production of anaerobiosis, decreasing the output of liquids, and preventing, in large injuries, dehydration and loss of electrolytes. The film can be removed merely by wetting. This composition is stable, does not require special conditions for stocking, and a single container may be used for several applications.

Compositions for the treatment of skin injuries

Stable, clear, antimicrobially effective, ophthalmic formulations are disclosed which provide an antimicrobially effective preservative. The formulations include an ophthalmologically effective amount of a drug, which is a --COOH group-containing non-steroidal anti-inflammatory drug (NSAID) alone or in combination with an antibiotic drug, and a preservative system formed of a quaternary ammonium preservative and a nonionic polyoxyethylated octylphenol surfactant, all in an aqueous vehicle. The preservative system can be used with other formulations which require the preservative to be ophthamologically acceptable and antimicrobially effective. These formulations are useful for treating diseases and/or conditions that are either caused by, associated with or accompanied by inflammatory processes, including, among others, glaucoma, cystoid macular edema, uveitis, diabetic retinopathy and conjunctivitis, or any trauma caused by eye surgery or eye injury. When the formulation is further comprised of an ophthalmologically acceptable antibiotic, the antibiotic is preferably tobramycin which has been found not to interfere with the rate of diffusion of the NSAID. The combination of the NSAID and antibiotic is particularly effective in simultaneously preventing and/or eliminating infection while preventing and/or eliminating inflammation.

Syntex

Inc.

Preservative system for ophthalmic formulations

The present invention relates to a pharmaceutical composition for preventing and treating an inflammatory disease, including a mixture of extracts from Trachelospermi Caulis and Paeonia Suffruticosa Andrews as an active ingredient and method for preparing the same. Also, a quasi-drug composition, a health functional food composition and a cosmetic composition, all based on the mixture, are provided for preventing or improving inflammation. In addition, the present invention relates to a method for treating an inflammatory disease by administering the pharmaceutical composition to a subject suspected of having the inflammatory disease. Containing the extract mixture, the composition exhibits excellent anti-inflammatory activity and edema-suppressing activity, compared to individual extracts, and thus can be applied to the prevention, treatment or improvement of an inflammatory disease. As natural materials, the extracts can be used as a safe therapeutic relatively free of fungal infection or other side-effects, compared to synthetic medicines. In addition, the known physiological activities of the extracts from Trachelospermi Caulis and Paeonia Suffruticosa Andrews including antibacterial activity, bone reinforcement, antiphlogistic activity, blood nourishment, vigoration, etc. may bring about a synergistic effect on the prevention, treatment and improvement of an inflammatory disease.

Lee; Jeong Min

Park; Jae Won

Choi; Jung Ho

Noh; Ill Chan

Kim; Se Na

Lee; Young June

Choi; Kyu Seok

Choi; Ji Na

Choi; Whan Soo

Hong; Jin Tea

SINIL PHARMACEUTICAL CO., LTD.

Pharmaceutical composition for preventing or treating inflammatory diseases comprising trachelospermi caulis extract and paeonia suffruticosa andrews extract, and method for preparing the same

antibiotic

ödéma

edema

antibiotic/ödéma

Compositions for the treatment of skin injuries

Preservative system for ophthalmic formulations

Pharmaceutical composition for preventing or treating inflammatory diseases comprising trachelospermi caulis extract and paeonia suffruticosa andrews extract, and method for preparing the same

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