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antitussives/emlőrák

A hivatkozás a vágólapra kerül
CikkekKlinikai vizsgálatokSzabadalmak
10 eredmények

Enhanced noscapine delivery using estrogen-receptor-targeted nanoparticles for breast cancer therapy.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Noscapine (Nos), an orally available plant-derived antitussive alkaloid, is in phase II clinical trials for cancer chemotherapy. It has extensively been shown to inhibit tumor growth in nude mice bearing human xenografts of hematopoietic, breast, lung, ovarian, brain, and prostate origin. However,
Drug delivery systems such as nanoparticles can provide enhanced efficacy for anticancer agents. Noscapine, a widely used cough suppressant for decades has recently been shown to cause significant inhibition and regression of tumor volumes without any detectable toxicity in cells or tissues.

Apoptotic effect of noscapine in breast cancer cell lines.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Cancer is a public health problem in the world and breast cancer is the most frequently cancer in women. Approximately 15% of the breast cancers are triple-negative. Apoptosis regulates normal growth, homeostasis, development, embryogenesis and appropriate strategy to treat cancer. Bax is a protein

Synthesis and biological evaluation of N-substituted noscapine analogues.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Noscapine is a phthalideisoquinoline alkaloid isolated from the opium poppy Papaver somniferum. It has long been used as an antitussive agent, but has more recently been found to possess microtubule-modulating properties and anticancer activity. Herein we report the synthesis and pharmacological

A new antiproliferative noscapine analogue: chemical synthesis and biological evaluation.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Noscapine, a naturally occurring opium alkaloid, is a widely used antitussive medication. Noscapine has low toxicity and recently it was also found to possess cytotoxic activity which led to the development of many noscapine analogues. In this paper we report on the synthesis and testing of a novel

Insights into the structure and tubulin-targeted anticancer potential of N-(3-bromobenzyl) noscapine.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
BACKGROUND Noscapine is a non-narcotic, antitussive alkaloid isolated from plants of Papaveraceae family. This benzylisoquinoline alkaloid and its synthetic derivatives, called noscapinoids, are being evaluated for their anticancer potential. METHODS The structure of a novel analogue,

[Topics from "Overseas Drug Safety Information" in the past five years].

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The Drug Safety Information Section of the Division of Safety Information on Drug, Food and Chemicals has been providing bulletins titled "Overseas Drug Safety Information" in Japanese since 2003. These bulletins comprise summarized and translated reports of important post-marketing drug safety
Docetaxel (DOX) based combination therapy is a novel therapeutic strategy that attracts great interest in breast cancer treatment but its clinical utility got limited due to side effects. In contrast, noscapine, an antitussive drug showed antitumor activity against many cancers without any side

Material basis, effect, and mechanism of ethanol extract of Pinellia ternata tubers on oxidative stress-induced cell senescence

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Background: The tuber of Pinellia ternata has been used for a thousand years in China. P. ternata possessed the activities of anti-emetic, sedative-hypnotic, anti-cancer, anti-asthmatic, anti-tussive, and anti-inflammatory. It is the
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