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arecoline/epilepsziás roham

A hivatkozás a vágólapra kerül
CikkekKlinikai vizsgálatokSzabadalmak
Oldal 1 tól től 18 eredmények

Gastric mucosal damage induced by arecoline seizure in rats.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
In an attempt to know the relation of seizure and gastric mucosal damage, we challenged arecoline (ACL) centrally to induce seizure and investigated gastric hemorrhagic injury in acid-irrigated stomachs of rats. The protective effects of several drugs also were evaluated. After deprivation of food
The effects of central norepinephrine depletion produced by DSP-4 on drug-induced catalepsy and pot-decapitation convulsions were examined in the rat. Haloperidol-induced catalepsy was potentiated in DSP-4 treated rats, while arecoline-induced catalepsy was attenuated. Furthermore, post-decapitation

On some relationships between gamma-aminobutyric acid (GABA) and the cholinergic mechanisms in pentylenetetrazol convulsions.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
In experiments on albino mice with pentylenetetrazol convulsions it has been found that GABA, introduced intracerebroventricularly in a dose of 100 microgram/mouse, has a marked anticonvulsive effect. Scopolamine in doses of 1, 10 and 50 mg/kg i. p. does not influence significantly the
Vaccination of children with Diphtheria, Tetanus, Poliomyelitis and pertussis vaccine (DTPoP-vaccine) containing the whole-cell pertussis component is known to be associated with manifestation of side-effects such as acute encephalopathy, convulsions and hypotensive-hyporesponsive episodes. In young

Anti-nicotinic properties of anticholinergic antiparkinson drugs.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The nature of the antagonism by anticholinergic compounds of nicotine-induced convulsion in mice has not been defined clearly. Although, because they do not compete effectively for agonist binding to brain tissue in-vitro, these compounds are thought to be non-competitive antagonists in the brain,

[Antagonism of the novel cholinolytic tricyclopinate on nicotinic and muscarinic cholinergic receptors].

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Tricyclopinate hydrochloride(TCPN.HCl) and methiodide(TCPN.CH3I) have been identified as new chemical entities. The effects of these two compounds on central and peripheral nicotinic and muscarinic cholinergic receptor activities were investigated. Excitation of the central nicotinic receptors by

[The spectrum of the anticonvulsant action of morfolid ].

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The albino experiments have shown that morpholide has an anticonvulsant effect in electroshock-, corazole-, thiosemicarbazide-, bicuculline-, strychnine-, arecoline-, nicotine-, tremorine-induced convulsions and tremors. The agent has a wider range of pharmacological effects than phenobarbital.

Anticholinergic activity in mice and receptor-binding properties in rats of a series of synthetic tropane derivatives.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
A tropane ester, three tropane ethers, atropine and mecamylamine were compared in mice for their anti-muscarinic and anti-nicotinic activity against arecoline-induced tremor and nicotine-induced convulsions, respectively. Their receptor-binding characteristics were studied in neuronal membranes

[Participation of m- and n-cholinergic mechanisms in the development of the kindling phenomenon of the amygdala in cats].

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The kindling phenomenon was produced after chronic electrostimulation of the cat amygdala. The duration and intensity of petit mal and grand mal were recorded. The M-cholinomimetic arecoline (0.3 mg/kg), the acetylcholinesterase inhibitor galanthamine (1-3 mg/kg) and the N-cholinergic blockers

[The anticonvulsant properties of glutapyrone--a new type of derivative of amino acid-containing 1,4-dihydropyridines].

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Experiments on male Wistar rats and Icr:Icl mice studied the influence of the novel compound--amino acid-containing 1,4-dihydropyridine derivative glutapyrone (G) on acute generalized seizures, arecoline and nicotine tremor, and 45Ca2+ uptake in brain synaptosomes. It was shown that G produced

Status epilepticus is produced by administration of cholinergic agonists to lithium-treated rats: comparison with kainic acid.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Electroencephalographic techniques were used to study generalized convulsive status epilepticus induced by administration of subconvulsive doses of cholinomimetics (e.g., pilocarpine) to rats pretreated with lithium chloride. Status epilepticus induced by this treatment was compared with status
Studies were performed to determine if the reported 'proconvulsant' action of lithium in rats given cholinergic drugs is related to receptor-initiated phospholipase A2 signaling via arachidonic acid. Regional brain incorporation coefficients k* of intravenously injected [1-14C]arachidonic acid,

Regulatory effects of acutely repeated nicotine treatment towards central muscarinic receptors.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Sensitivity of brain muscarinic acetylcholine receptors to the agonists was examined in nicotine tolerant animals which were developed by acutely repeated injections of nicotine. In conscious rats, the dose-response curves of muscarinic agonists arecoline and pilocarpine, cholinesterase inhibitors

Nonmuscarinic neurotoxicity of oxotremorine.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The ability of various treatments to prevent peripheral parasympathetic actions, central effects and lethality of the muscarinic agonist oxotremorine was studied in rats. The percentage of animals exhibiting effects of oxotremorine was dose and time dependent. The ED50 for producing lacrimation,
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