beta carotene/hypoxia

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Antioxidant effect of beta-carotene on hypoxia induced oxidative stress in male albino rats.

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Hypoxia is known to induce oxidative stress in organisms leading to tissue injury. In the present study beta-carotene (BC) given at 10 mg/kg body weight (BW) in reducing the oxidative stress induced by hypoxia was evaluated on male albino rats. Hypoxia exposure caused an increase in malondialdehyde

β-Carotene inhibits neuroblastoma cell invasion and metastasis in vitro and in vivo by decreasing level of hypoxia-inducible factor-1α.

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Neuroblastoma is the most prevalent extracranial solid tumor in childhood and has poor clinical outcome due to its high potential for metastasis. Consequently, an understanding of the mechanisms that modulate cancer cell invasion, migration and metastasis is important for the development of more

Effects of exercise and training in hypoxia on antioxidant/pro-oxidant balance.

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OBJECTIVE The aim was to investigate the effects of acute exercise under hypoxic condition and the repetition of such exercise in a 'living low-training high' training on the antioxidant/prooxidant balance. METHODS Randomized, repeated measures design. METHODS Faculté de Médecine, Clermont-Ferrand,

Cyto- and genotoxic potential of beta-carotene and cleavage products under oxidative stress.

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Free radical attack on beta-carotene results in the formation of high amounts of cleavage products with prooxidant activities towards subcellular organelles such as mitochondria, a finding which could provide an explanation for the contradictory results obtained with beta-carotene in clinical

Dietary β-carotene regulates interleukin-1β-induced expression of apolipoprotein E in astrocytes isolated from stroke-prone spontaneously hypertensive rats.

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Stroke-prone spontaneously hypertensive rats (SHRSP) have an abnormality in cholesterol synthesis, but the pathological relevance of this to stroke and related neuronal disorders is not yet clear. The induction of astrocyte-derived cholesterol transportation to neurons by apolipoprotein E (apoE)

Beta-carotene breakdown products enhance genotoxic effects of oxidative stress in primary rat hepatocytes.

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Since it has to be expected that individuals exposed to oxidative stress who take supplements of beta-carotene are simultaneously exposed to both beta-carotene cleavage products (CPs) and oxidative stress, and both exposures have been demonstrated to cause genotoxic effects in primary rat

Regulation of heme oxygenase-1 gene expression by anoxia and reoxygenation in primary rat hepatocyte cultures.

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Heme oxygenase (HO) catalyzes the rate-limiting enzymatic step of heme degradation and regulates the cellular heme content. Gene expression of the inducible isoform of HO, HO-1, is upregulated in response to various oxidative stress stimuli. To investigate the regulatory role of anoxia and

Effects of antioxidant supplementation on exercise performance in acute normobaric hypoxia.

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OBJECTIVE To compare the effects of a 3-week supplementation between two different mixtures of antioxidants and placebo on aerobic exercise performance in acute normobaric hypoxia. METHODS Seventeen subjects were randomly assigned in a double-blind fashion to receive a broad-based antioxidants

Antiteratogenic Effects of β-Carotene in Cultured Mouse Embryos Exposed to Nicotine.

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After maternal intake, nicotine crosses the placental barrier and causes severe embryonic disorders and fetal death. In this study, we investigated whether β -carotene has a beneficial effect against nicotine-induced teratogenesis in mouse embryos (embryonic day 8.5) cultured for 48 h in a whole

Role of selenium in reducing hypoxia-induced oxidative stress: an in vivo study.

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At high altitudes, the reactive oxygen species are continuously generated as a consequence of low oxygen partial pressure (hypoxia), which causes tissue damage. The body's defence system to combat the oxidative stress (e.g., anti-oxidant enzymes, free radical scavengers such as vitamin C, vitamin E,

Binding studies and biological evaluation of β-carotene as a potential inhibitor of human calcium/calmodulin-dependent protein kinase IV.

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Human calcium/calmodulin-dependent protein kinase IV (CAMKIV), a member of Ser/Thr kinase family, is associated with cancer, cerebral hypoxia and neurodegenerative diseases. β-carotene is a colored organic compound, abundant in plants and fruits and is used in cancer prevention. Here, we report a

[Vitamins and oxidative stress].

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The central and local stress limiting systems, including the antioxidant defense system involved in defending the organism at the cellular and systemic levels from excess activation response to stress influence, leading to damaging effects. The development of stress, regardless of its nature [cold,

Effect of antioxidant supplementation on urine and blood markers of oxidative stress during extended moderate-altitude training.

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OBJECTIVE To investigate the increase in oxidative stress during work at moderate altitudes due to additional energy expenditure, tissue anoxia, and UV light exposure. METHODS Thirty US Marine Corps volunteers were divided into placebo (P) and antioxidant supplement (S) groups and tested for markers

Oxidant status, iron homeostasis, and carotenoid levels of COPD patients with advanced disease and LTOT.

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Background: The pathogenesis of chronic obstructive pulmonary disease (COPD) is associated with oxidative stress. Both iron (Fe) and oxygen are involved in the chemical reactions that lead to increased formation of reactive oxygen species. Oxidative reactions are prevented by antioxidants such as

Antioxidant supplementation does not attenuate oxidative stress at high altitude.

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BACKGROUND Hypobaric hypoxia and heightened metabolic rate increase free radical production. OBJECTIVE We tested the hypothesis that antioxidant supplementation would reduce oxidative stress associated with increased energy expenditure (negative energy balance) at high altitude (HA 4300

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