cholangiocarcinoma/glutation

A hivatkozás a vágólapra kerül

Válasszon rendezési típust

Oldal 1 tól től 54 eredmények

Halogenated hydrocarbon solvent-related cholangiocarcinoma risk: biliary excretion of glutathione conjugates of 1,2-dichloropropane evidenced by untargeted metabolomics analysis.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Recently, the International Agency for Research on Cancer issued a warning about the carcinogenicity of 1,2-dichloropropane (1,2-DCP) to humans based on an epidemiological study suggesting a relationship between the incidence of cholangiocarcinoma and occupational exposure to halogenated hydrocarbon

Suppression of glutathione S-transferases potentiates the cytotoxic effect of phenethyl isothiocyanate in cholangiocarcinoma cells.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Phenethyl isothiocyanate (PEITC) is a potential cancer prevention agent that is found in cruciferous vegetables. Previous studies have shown that the effect of PEITC-induced cell death declines rapidly after administration. The metabolic fate of PEITC is modulated by glutathione S-transferases

Reversal of multiple drug resistance in cholangiocarcinoma by the glutathione S-transferase-pi-specific inhibitor O1-hexadecyl-gamma-glutamyl-S-benzylcysteinyl-D-phenylglycine ethylester.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Cholangiocarcinoma is markedly resistant to chemotherapy and has a dismal prognosis, but its mechanism of drug resistance is unknown. This study examines whether glutathione S-transferase-pi (GSTP1-1) is involved in resistance to anticancer drugs in cholangiocarcinoma and whether GSTP1-1-specific

Phenethyl isothiocyanate induces apoptosis of cholangiocarcinoma cells through interruption of glutathione and mitochondrial pathway.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Phenethyl isothiocyanate (PEITC) is a natural isothiocyanate with anticancer activity against many drug-resistant cancer cells. A body of evidence suggests that PEITC enhances oxidative stress leading to cancer cell death. Cholangiocarcinoma (CCA) is an aggressive bile duct cancer with resistance to

Secreted Opisthorchis viverrini glutathione S-transferase regulates cell proliferation through AKT and ERK pathways in cholangiocarcinoma.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Opisthorchis viverrini can develop mitogenic substances into the excretory/secretory product (ESP) that may play an important role in promoting the genesis of cholangiocarcinoma (CCA). In the present study, glutathione S-transferase (GST) is identified as being secreted into Ov-ESP and acting as one

Spontaneous Production of Glutathione-Conjugated Forms of 1,2-Dichloropropane: Comparative Study on Metabolic Activation Processes of Dihaloalkanes Associated with Occupational Cholangiocarcinoma.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Recently, epidemiological studies revealed a positive relationship between an outbreak of occupational cholangiocarcinoma and exposure to organic solvents containing 1,2-dichloropropane (1,2-DCP). In 1,2-DCP-administered animal models, we previously found biliary excretion of potentially oncogenic

A trial to find appropriate animal models of dichloropropane-induced cholangiocarcinoma based on the hepatic distribution of glutathione S-transferases.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

OBJECTIVE It has been reported that 1,2-Dichloropropane (DCP) induced cholangiocarcinoma (CCA) in offset color proof-printing workers. However, exposure to DCP by inhalation or gavage for 2 year did not induce CCA in mice and rats. The present study mapped the hepatic distribution of GST, which is

Genetic polymorphism of drug metabolizing enzymes in association with risk of bile duct cancer.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Cholangiocarcinoma (CCA) is the most common cancer in endemic areas of liver fluke infection. Although the liver fluke is recognized as a carcinogenic agent in cholangiocarcinogenesis, other factors may play important roles in bringing about the high prevalence of the cancer in populations of this

Characterization and in vitro functional analysis of thioredoxin glutathione reductase from the liver fluke Opisthorchis viverrini

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

The carcinogenic liver fluke Opisthorchis viverrini causes several hepatobiliary diseases including a bile duct cancer-cholangiocarcinoma (CCA), which is a major public health problem in many countries in the Greater Mekong Sub-region. Praziquantel is the main drug against this parasite, however,

Inflammatory cytokines suppress arylamine N-acetyltransferase 1 in cholangiocarcinoma cells.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

OBJECTIVE To evaluate the effect of inflammatory cytokines on arylamine N-acetyltransferase 1 (NAT1), which is a phase-II enzyme involved in the biotransformation of aromatic and heterocyclic amines found in food, drugs and the environment. METHODS Human cholangiocarcinoma KKU-100 cells were treated

Inflammatory cytokines suppress NAD(P)H:quinone oxidoreductase-1 and induce oxidative stress in cholangiocarcinoma cells.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

OBJECTIVE The aim of this study was to evaluate the effect of inflammation on NAD(P)H: quinone oxidoreductase-1 (NQO1), the xenobiotic metabolizing and antioxidant enzyme protecting cells against electrophiles and reactive oxygen species in biliary cancer (cholangiocarcinoma) cells. METHODS Human

Combined effects of polymorphisms of DNA-repair protein genes and metabolic enzyme genes on the risk of cholangiocarcinoma.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

OBJECTIVE Although Opisthorchis viverrini is a risk factor for cholangiocarcinoma, not all the infected individuals develop cholangiocarcinoma. We investigated whether the base excision repair enzyme gene polymorphisms with differentiated repair capacities of inflammation-related deoxyribonucleic

Defensive mechanism in cholangiocarcinoma cells against oxidative stress induced by chlorin e6-based photodynamic therapy.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

In this study, the effect of chlorin e6-based photodynamic therapy (Ce6-PDT) was investigated in human intrahepatic (HuCC-T1) and extrahepatic (SNU1196) cholangiocarcinoma (CCA) cells. The amount of intracellular Ce6 increased with increasing Ce6 concentration administered, or with incubation time,

Identification of S-acyl glutathione conjugates of bile acids in human bile by means of LC/ESI-MS.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Previous work from this laboratory has reported the biotransformation of bile acids (BA) into the thioester-linked glutathione (GSH) conjugates via the intermediary metabolites formed by BA:CoA ligase and shown that such GSH conjugates are excreted into the bile in healthy rats as well as rats dosed

Change in alpha glutathione s-transferase levels during liver resection.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

OBJECTIVE Alpha-glutathione s-transferase (GST) is a 50,000-kDa cytosol protein of the hepatocytes. It comprises 5% of the soluble protein of hepatocytes and is readily released in response to injury. Its half-life time is 60 minutes (AST: 47 hrs, ALT: 22 hrs). The aim of this study is to clarify

Előző
1
2
3
4
Következő

Csatlakozzon
facebook oldalunkhoz

Herbal & Natural Medicine

A legteljesebb gyógynövény-adatbázis, amelyet a tudomány támogat

Működik 55 nyelven
A tudomány által támogatott gyógynövényes kúrák
Gyógynövények felismerése kép alapján
Interaktív GPS térkép - jelölje meg a gyógynövényeket a helyszínen (hamarosan)
Olvassa el a keresésével kapcsolatos tudományos publikációkat
Keresse meg a gyógynövényeket hatásuk szerint
Szervezze meg érdeklődését, és naprakész legyen a hírkutatással, a klinikai vizsgálatokkal és a szabadalmakkal

Írjon be egy tünetet vagy betegséget, és olvassa el azokat a gyógynövényeket, amelyek segíthetnek, beírhat egy gyógynövényt, és megtekintheti azokat a betegségeket és tüneteket, amelyek ellen használják.
* Minden információ publikált tudományos kutatáson alapul