glucosidase/vérzés

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Small molecule inhibitors of ER α-glucosidases are active against multiple hemorrhagic fever viruses.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Host cellular endoplasmic reticulum α-glucosidases I and II are essential for the maturation of viral glycosylated envelope proteins that use the calnexin mediated folding pathway. Inhibition of these glycan processing enzymes leads to the misfolding and degradation of these viral glycoproteins and

Enhancing the antiviral potency of ER α-glucosidase inhibitor IHVR-19029 against hemorrhagic fever viruses in vitro and in vivo.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Targeting host functions essential for viral replication has been considered as a broad spectrum and resistance-refractory antiviral approach. However, only a few host functions have, thus far, been validated as broad-spectrum antiviral targets in vivo. ER α-glucosidases I and II have been

A case of adult type 1 Gaucher disease complicated by temporal intestinal hemorrhage.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

A 21-year-old man with a history of sudden rectal hemorrhage was referred to our hospital. Examination disclosed thrombocytopenia and hepatosplenomegaly. A liver biopsy specimen demonstrated Gaucher cells in Glisson's capsule. Additional investigations revealed a low level of leukocyte β-glucosidase

Measurement of alpha-glucosidase activity in serum from patients with cystic fibrosis or pancreatitis.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

We measured the activity of a non-lysosomal alpha-glucosidase with pH optimum near 6.0 in serum from a wide variety of patients, using the fluorogenic substrate, 4-methylumbelliferyl-alpha-D-glucopyranoside. Acutely ill patients with cystic fibrosis (CF) demonstrated significant increases in

Efficient Synthesis and in Silico Studies of the Benzimidazole Hybrid Scaffold with the Quinolinyloxadiazole Skeleton with Potential α-Glucosidase Inhibitory, Anticoagulant, and Antiplatelet Activities for Type-II Diabetes Mellitus Management and Treating Thrombotic Disorders.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

The current study evaluates antidiabetic, anticoagulant, and antiplatelet activity of novel benzimidazole-containing quinolinyl oxadiazoles. These derivatives are synthesized and characterized using spectroscopy (FT-IR, 1H NMR, and mass spectroscopy) and single-crystal X-ray diffraction methods. The

Intestinal alpha-glucosidase inhibitors: abdominal gas cysts.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Detailed imaging studies of gas cysts in the intestinal mucosa (pneumatosis cystoides intestinalis) have been reported in around 20 patients taking acarbose, miglitolor voglibose, i.e. intestinal alpha-glucosidase inhibitors used as hypoglycaemic agents. Almost all the patients had nonspecific

Competitive inhibitor of cellular α-glucosidases protects mice from lethal dengue virus infection.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Dengue virus infection causes diseases in people, ranging from the acute febrile illness dengue fever, to life-threatening dengue hemorrhagic fever/dengue shock syndrome. We previously reported that a host cellular α-glucosidases I and II inhibitor, imino sugar CM-10-18, potently inhibited dengue

Imino sugar glucosidase inhibitors as broadly active anti-filovirus agents.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Ebola virus and Marburg virus are members of the family of Filoviridae and are etiological agents of a deadly hemorrhagic fever disease. The clinical symptoms of Ebola and Marburg hemorrhagic fevers are difficult to distinguish and there are currently no specific antiviral therapies against either

Effect of glucocorticoids on release of lysosomal enzymes in liver ischemia and hemorrhagic shock in pigs.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

The effect of glucocorticoids on the release of lysosomal enzymes was studied in liver ischemia created by dearterialization and in hemorrhagic shock in pigs. In shock the treatment with glucocoticoids suppressed the release of beta-glucosidase and beta-galactosidase into the circulation. The

Glitazones and alpha-glucosidase inhibitors as the second-line oral anti-diabetic agents added to metformin reduce cardiovascular risk in Type 2 diabetes patients: a nationwide cohort observational study.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Metformin is the standard first-line drug for patients with Type 2 diabetes (T2DM). However, the optimal second-line oral anti-diabetic agent (ADA) remains unclear. We investigated the cardiovascular risk of various ADAs used as add-on medication to metformin in T2DM patients from a nationwide

[Occurrence of ileus after voglibose treatment in an elderly diabetic patient with gait disturbance caused by cerebral hemorrhage].

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Alpha-glucosidase inhibitor can suppress postprandial hyperglycemia by delaying the absorption of carbohydrates in the intestine, and may be useful in obese patients with non-insulin-dependent diabetes mellitus (NIDDM) and preserved insulin secretion. We encountered an obese elderly patient with

Antiviral therapies targeting host ER alpha-glucosidases: current status and future directions.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Endoplasmic reticulum (ER)-resident α-glucosidases I and II sequentially trim the three terminal glucose moieties on N-linked glycans attached to nascent glycoproteins. These reactions are the first steps of N-linked glycan processing and are essential for proper folding and function of many

[Cavernoma complicated with biliopatia secondary to type 1 Gaucher disease: report of a Peruvian case].

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Gaucher disease is an autosomal recessive lysosomal storage disorder characterized by deficiency of beta-glucosidase that would lead to the accumulation of glucosylceramide mainly in cells of the mononuclear phagocytic system causing systemic effectations. We present a patient of twenty years who is

Proteomic analysis of primary porcine endothelial cells after infection by classical swine fever virus.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Endothelial cells are the main target of classical swine fever virus during infection, and extensive hemorrhage is the most typical clinical sign of classical swine fever. To investigate the molecular mechanism of hemorrhagic pathogenesis, two-dimensional difference gel electrophoresis with

Mild thrombocytopenia as presenting symptom of type 1 Gauchers's disease.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

A young woman was examined for a mild thrombocytopenia which was present for some months. No signs of bleeding had so far occurred. Physical examination was normal except for a moderately enlarged spleen. Laboratory investigations showed a low platelet count. There was no evidence of an autoimmune

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