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glutathione/rák

A hivatkozás a vágólapra kerül
Oldal 1 tól től 58 eredmények
This invention relates to a method of determining human acid glutathione S-transferase in a human assay sample, a reagent therefor, a kit therefor, a method of diagnosing cancer in digestive organs, and to a monoclonal antibody. Particularly, it relates to a method of determining human acid

S-dimethylarsino-thiosuccinic acid S-dimethylarsino-2-thiobenzoic acid S-(dimethylarsino) glutathione as treatments for cancer

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
BACKGROUND OF THE INVENTION I. Field of the Invention The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides organic arsenic compounds and methods for their use in treating cancers such as leukemia. II. Description of Related Art Despite progress

S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
I. Field of the Invention The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides organic arsenic compounds and methods for their use in treating cancers such as leukemia. II. Description of Related Art Despite progress in leukemia therapy, most

S-dimethylarsino-thiosuccinic acid s-dimethylarsino-2-thiobenzoic acid s-(dimethylarsino) glutathione as treatments for cancer

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
BACKGROUND OF THE INVENTION I. Field of the Invention The present invention relates generally to the field of anti-cancer therapy. More particularly, it provides organic arsenic compounds and methods for their use in treating cancers such as leukemia. II. Description of Related Art Despite progress

Glutathione N-hydroxycarbamoyl thioesters and method of inhibiting neoplastic growth

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the use of novel S(N-hydroxycarbamoyl) glutathione mono- and di-ester derivatives as potent cytotoxic and anti-tumorigenic agents, and to a method of treating tumorigenic diseases with these derivatives.

Use of substituted acryloyl distamycin derivatives in the treatment of tumors associated with high levels of glutathione

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The present invention relates to the use of substituted acryloyl distamycin derivatives, in particular to the use of .alpha.-bromo- and .alpha.-chloroacryloyl distamycin derivatives, in the treatment of tumors associated with high levels of glutathione and/or glutathione-S-transferases family. More

Inhibition of glutathione transferase by haloenol lactones

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
FIELD OF THE INVENTION This invention relates to novel haloenol lactone compounds. These compounds are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. The measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The

Inhibition of glutathione transferase by haloenol lactones

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
FIELD OF THE INVENTION This invention relates to novel haloenol lactone compounds. These compounds are useful for the specific measurement of particular isoenzymes of glutathione S-transferase. The measurement of glutathione S-transferase isoenzymes has importance in diagnostic medicine. The

Peptidomimetic glutathione analogs

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Belépés Regisztrálás
FIELD OF THE INVENTION The invention relates to peptidomimetic compounds which are novel analogs of glutathione. The invention also relates to pharmaceutical compositions comprising such glutathione analogs. The novel analogs are useful as inhibitors of glutathione S-transferase, in particular of

Glutathione s-transferase

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
FIELD OF THE INVENTION This invention relates to nucleic acid and amino acid sequences of a novel glutathione s-transferase and to the use of these sequences in the diagnosis, prevention, and treatment of cancer. BACKGROUND OF THE INVENTION The glutathione s-transferases (GST) are a ubiquitous

Glutathione s-transferase

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
FIELD OF THE INVENTION This invention relates to nucleic acid and amino acid sequences of a novel glutathione S-transferase and to the use of these sequences in the diagnosis, prevention, and treatment of cancer. BACKGROUND OF THE INVENTION The glutathione S-transferases (GST) are a ubiquitous

In vivo use of glutathione S-transferase activated nitric oxide donors

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
BACKGROUND OF THE INVENTION Nitric oxide (NO) is integral to many biological processes including the control of blood pressure, protection against microbial infection and neurotransmission. Additionally, it appears to be a potent cytotoxin to tumor cells. Among its mechanisms of action on malignant

Structural-based inhibitors of the glutathione binding site in aldose reductase, methods of screening therefor and methods of use

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to the fields of enzymology, protein structure and drug screening. More specifically, the present invention relates to the use of a crystalline structure of an aldose reductase complexed with NADPH and

Method and compositions for treating tumors having high tyrosinase activity

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
FIELD OF THE INVENTION The present invention is directed to methods and compositions for treating tumors and other metastatic diseases exhibiting high tyrosinase and saccharide enzyme activity. The invention is further directed to methods and compositions for treating tumors having high tyrosinase

Method and compositions for treating tumors having high tyrosinase activity

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
FIELD OF THE INVENTION The present invention is directed to methods and compositions for treating tumors and other metastatic diseases exhibiting high tyrosinase and .beta.-glucuronidase activity. The invention is further directed to methods and compositions for treating tumors having high
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