11 eredmények
DESCRIPTION OF THE INVENTION
This invention relates to a method of increasing the activity of Herpes Simplex Virus protease by including kosmotropic anion in a reaction medium and to assays which involve the activated protease.
BACKGROUND OF THE INVENTION
Herpes Simplex Virus type 1 (HSV-1) protease
This invention is directed to a novel method for purifying herpes simplex viral protease.
BACKGROUND OF THE INVENTION
The Herpes Group of viruses includes many viruses which are pathogenic in humans, such as Herpes Simplex Virus (HSV), Varicella Zoster Virus (VZV), Cytomegalovirus (CMV), and
BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates to the identification and purification of herpes proteases and to nucleic acid segments coding for such proteases. The present invention also relates to methods of selecting candidate substances that are able to
FIELD OF THE INVENTION
This invention relates to reagents and a method for determining the activity of herpesvirus proteases. More particularly, the invention relates to fluorogenic substrates and a fluorometric assay for CMV protease and other herpesvirus proteases.
BACKGROUND OF THE
FIELD OF THE INVENTION
This invention relates to reagents and a method for determining the activity of herpesvirus proteases. More particularly, the invention relates to fluorogenic substrates and a fluorometric assay for CMV protease and other herpesvirus proteases.
BACKGROUND OF THE
TECHNICAL FIELD OF THE INVENTION
The invention relates to the identification of a novel protease catalytic active site and methods for enabling the design and selection of inhibitors of proteases, esterases, ligases and other hydrolases with that active site.
BACKGROUND OF THE
TECHNICAL FIELD OF THE INVENTION
The invention relates to the identification of a novel protease catalytic active site and methods for enabling the design and selection of inhibitors of proteases, esterases, ligases and other hydrolases with that active site.
BACKGROUND OF THE
TECHNICAL FIELD OF THE INVENTION
The invention relates to the identification of protease inhibitors.
BACKGROUND OF THE INVENTION
An undesirable level of protease activity occurs in a variety of conditions, including rheumatoid arthritis and other autoimmune diseases, tumor invasion, inflammation,
FIELD OF THE INVENTION
The present invention relates to peptides having antiviral activity and to means for using the peptides to treat viral infections. More specifically, this invention relates to oligopeptides having antiviral properties, to processes for their production, to pharmaceutical
FIELD OF THE INVENTION
The present invention relates to peptides having antiviral activity and to means for using the peptides to treat viral infections. More specifically, this invention relates to oligopeptides having antiviral properties, to processes for their production, to pharmaceutical
BACKGROUND
While the development of antibiotics has revolutionized medicine, effective treatment of viral infections has proved to be more elusive. In particular, chronic infections, such as those associated with retroviruses and herpesviruses, are considerable health problems, particularly for