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ketone/agyi érkatasztrófa

A hivatkozás a vágólapra kerül
Oldal 1 tól től 65 eredmények

Sirtuin 3 mediates neuroprotection of ketones against ischemic stroke.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Stroke is one of the leading causes of death. Growing evidence indicates that ketone bodies have beneficial effects in treating stroke, but their underlying mechanism remains unclear. Our previous study showed ketone bodies reduced reactive oxygen species by using NADH as an electron donor, thus

Emissions of aldehydes and ketones from a two-stroke engine using ethanol and ethanol-blended gasoline as fuel.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Besides aliphatic gasoline, ethanol-blended gasoline intended for use in small utility engines was recently introduced on the Swedish market. For small utility engines, little data is available showing the effects of these fuels on exhaust emissions, especially concerning aldehydes and ketones

Stroke outcome in the ketogenic state--a systematic review of the animal data.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
As a predictor of potential clinical outcome, we performed a systematic review of controlled studies that assessed experimental stroke outcome in rodents maintained on special diets (calorie restriction and ketogenic diet) or following the direct administration of ketone bodies. Pre-clinical studies
OBJECTIVE Increased oxidative stress plays an important role in cardiovascular diseases including hypertension and stroke. Evidence has indicated that ketone bodies could exert antioxidative effects. We explored the role of renal mitochondrial 3-hydroxy-3-methylglutaryl-coenzyme A synthase (HMGCS2)
[reaction: see text] A task-specific ionic liquid, [bmIm]OH, has been introduced as a catalyst and as a reaction medium in Michael addition. Very interestingly, although the addition to alpha,beta-unsaturated ketones proceeds in the usual way, giving the monoaddition products, this ionic liquid
Laser-induced fluorescence of acetone and 3-pentanone for a 248 nm excitation wavelength was investigated for conditions relevant for internal combustion engines regarding temperature, pressure, and gas composition. An optically accessible calibration chamber with continuous gas flow was operated by
OBJECTIVE In conditions with reduced glucose levels/inability of glucose utilization, ketone bodies, especially beta-hydroxybutyrate (BHB), become a major energy source in the brain. In animal models, BHB infusion shows acute beneficial effects on the hypoxic brain. The present prospective

Protection from brain damage and bacterial infection in murine stroke by the novel caspase-inhibitor Q-VD-OPH.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Infarction size and infections are important determinants of stroke outcome in humans. Bacterial infections are promoted by stroke-induced immunodeficiency which in experimental stroke is mainly characterized by extensive lymphocyte apoptosis and dysfunction. Pharmacological inhibition of caspases

Stroke as the presenting feature of new onset diabetes in a young man.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
A 34-year-old man presented to a hospital with a 7-day history of nausea, vertigo, ataxia and frontal headache. Examination revealed ipsilateral cerebellar signs. CT of the brain demonstrated left cerebellar hypodensity suggestive of ischaemic stroke or space occupying lesion. Full blood count

Beta-Ketothiolase Deficiency Presenting with Metabolic Stroke After a Normal Newborn Screen in Two Individuals.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Beta-ketothiolase (mitochondrial acetoacetyl-CoA thiolase) deficiency is a genetic disorder characterized by impaired isoleucine catabolism and ketone body utilization that predisposes to episodic ketoacidosis. It results from biallelic pathogenic variants in the ACAT1 gene, encoding mitochondrial

Synthesis and biological activity of a series of potent fluoromethyl ketone inhibitors of recombinant human calpain I.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Calpain I, an intracellular cysteine protease, has been implicated in the neurodegeneration following an episode of stroke. In this paper, we report on a series of potent dipeptide fluoromethyl ketone inhibitors of recombinant human calpain I (rh calpain I). SAR studies revealed that while calpain I

The addition of ketone bodies alleviates mitochondrial dysfunction by restoring complex I assembly in a MELAS cellular model.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Ketogenic Diet used to treat refractory epilepsy for almost a century may represent a treatment option for mitochondrial disorders for which effective treatments are still lacking. Mitochondrial complex I deficiencies are involved in a broad spectrum of inherited diseases including Mitochondrial
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