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methyl palmitate/gyulladás

A hivatkozás a vágólapra kerül
CikkekKlinikai vizsgálatokSzabadalmak
Oldal 1 tól től 20 eredmények

Anti-inflammatory activity of methyl palmitate and ethyl palmitate in different experimental rat models.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Methyl palmitate (MP) and ethyl palmitate (EP) are naturally occurring fatty acid esters reported as inflammatory cell inhibitors. In the current study, the potential anti-inflammatory activity of MP and EP was evaluated in different experimental rat models. Results showed that MP and EP caused

Anti-inflammatory and antifibrotic effects of methyl palmitate.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Methyl palmitate (MP) has been shown earlier to inhibit Kupffer cells and rat peritoneal macrophages. To evaluate the potential of MP to inhibit the activation of other macrophages, RAW cells (macrophages of alveolar origin) were treated with varying concentrations of MP (0.25, 0.5, 1mM). Assessment

Methyl palmitate attenuates lipopolysaccharide-induced acute lung injury in mice.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
OBJECTIVE The study is aimed to determine the beneficial effects of methyl palmitate (MP) which has antioxidant and anti-inflammatory effects demonstrated on murine model of acute lung injury induced by lipopolysaccharide (LPS). METHODS Forty male BALB/C mice were randomly allocated into four groups

Effect of Methyl Palmitate on the Formation of Epidural Fibrosis in an Experimental Epidural Fibrosis Model.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
OBJECTIVE To investigate the effects of local and systemic administration of methyl palmitate on the formation of epidural fibrosis. METHODS Twenty-eight rats were randomly divided into four equal groups (control, Spongostan, local methyl palmitate and orally methyl palmitate) and laminectomy was

The effect of methyl palmitate on treatment of experimental asthma.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
OBJECTIVE To determine the effects of methyl palmitate on murine model of chronic asthma. METHODS The experimental study was conducted in the animal laboratory of DokuzEylul University, Turkey, from October to December, 2012, and comprised BALB/c mice whowere divided into four equal groups: three

Effects of methyl palmitate on cytokine release, liver injury and survival in mice with sepsis.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The effects of methyl palmitate (MP), a known inhibitor of Kupffer cells, were studied in a model of polymicrobial sepsis induced in CD-1 mice by cecal ligation and puncture (CLP). The inhibition of Kupffer cells by pretreatment with MP was shown by the reduced phagocytosis, the production of tumor

Does lipophilicity per se induce adjuvant effects? Methyl palmitate as model substance does not affect ovalbumin sensitization.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Anthopogenically introduced substances and pollutants are suspected to promote sensitization and development of allergic airway diseases, that is, acting as adjuvants. Lipophilicity may serve as an immunological warning signal, promoting adjuvant effects. Whether the lipophilicity of an inhaled

Cytoprotective potential of tiron and methyl palmitate against acetaminophen-induced acute liver injury.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Acute liver injury is a debilitating disorder associated with loss of synthetic and detoxifying functions of the liver. This investigation was designed to assess cytoprotective efficacy of daily oral tiron (300 mg/kg) and daily oral methyl palmitate (300 mg/kg) against acetaminophen-induced acute

Protective effects of methyl palmitate against silica-induced pulmonary fibrosis in rats.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Silicosis is one of the most prevalent chronic occupational pulmonary diseases worldwide. The present study aimed to investigate the effects of methyl palmitate on silica-induced lung fibrosis in rats and explore the possible mechanisms. Male Sprague-Dawley rats were divided into 3 groups: group I

Modulation of cyclophosphamide-induced cardiotoxicity by methyl palmitate.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Cyclophosphamide (CP) is a frequently used anticancer and immunosuppressant although its use has been associated with severe cardiotoxicity. The present study examined the ability of methyl palmitate (MP) to counteract CP-induced cardiotoxicity. Adult male Wistar rats were divided into four groups.

Targeting MAPKs, NF-κB, and PI3K/AKT pathways by methyl palmitate ameliorates ethanol-induced gastric mucosal injury in rats.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Excessive drinking of alcohol has been frequently associated with gastric injury; however, its underlying molecular mechanisms have been inadequately investigated. Methyl palmitate (MP) has demonstrated marked hepato-, cardio- and pulmonary protective features; however, its effects on

Methyl palmitate reversed estradiol benzoate-induced endometrial hyperplasia in female rats

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Early detection and treatment of endometrial hyperplasia(EH) is mandatory for endometrial cancer prevention. Several bioactive agents of plant origin have been shown to elicit their chemotherapeutic effect against tumors and cancer via induction of mitochondrial permeability transition(mPT) pore

Insights antifibrotic mechanism of methyl palmitate: impact on nuclear factor kappa B and proinflammatory cytokines.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Fibrosis accompanies most chronic liver disorders and is a major factor contributing to hepatic failure. Therefore, the need for an effective treatment is evident. The present study was designed to assess the potential antifibrotic effect of MP and whether MP can attenuate the severity of oxidative
BACKGROUND The present study investigated the potential of methanolic extract of Dicranopteris linearis (MEDL) leaves to attenuate liver intoxication induced by acetaminophen (APAP) in rats. METHODS A group of mice (n = 5) treated orally with a single dose (5000 mg/kg) of MEDL was first subjected to

Exacerbated liver injury of antithyroid drugs in endotoxin-treated mice.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Drug-induced liver injury is a major concern in clinical studies as well as in post-marketing surveillance. Previous evidence suggested that drug exposure during periods of inflammation could increase an individual's susceptibility to drug hepatoxicity. The antithyroid drugs, methimazole (MMI) and
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