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neurogenic inflammation/protease

A hivatkozás a vágólapra kerül
CikkekKlinikai vizsgálatokSzabadalmak
Oldal 1 tól től 44 eredmények

Self-maintenance of neurogenic inflammation contributes to a vicious cycle in skin.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Cutaneous neurogenic inflammation (CNI) is frequently associated with skin disorders. CNI is not limited to the retrograde signalling of nociceptive sensory nerve endings but can instead be regarded as a multicellular phenomenon. Thus, soluble mediators participating in communication among sensory
Proteases that cleave protease-activated receptor-2 (PAR(2)) at Arg(36)↓Ser(37) reveal a tethered ligand that binds to the cleaved receptor. PAR(2) activates transient receptor potential (TRP) channels of nociceptive neurons to induce neurogenic inflammation and pain. Although proteases that cleave

Protease-activated receptors in inflammation, neuronal signaling and pain.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The ability of proteases to regulate cell function via protease-activated receptors (PARs) has led to new insights about the potential physiological functions of these enzymes. Several studies suggest that PARs play roles in both inflammation and tissue repair, depending on the cellular environment

Protease-activated receptor 2 expression in trigeminal neurons innervating the rat nasal mucosa.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Protease-activated receptor 2 (PAR2) is activated by trypsin and mast cell tryptase to induce widespread inflammation by unknown mechanisms. Trypsin and tryptase were shown to activate sensory neurons to release substance-P and related peptides to mediate neurogenic inflammation. In the present

Expression of protease-activated receptor-1, -2, -3, and -4 in control and experimentally inflamed mouse bladder.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Inflammation underlines all major bladder pathologies and represents a defense reaction to injury involving a mandatory participation of mast cells and sensory nerves. Mast cells are particularly frequent in close proximity to epithelial surfaces where they are strategically located in the bladder

Protease-activated receptors: regulation of neuronal function.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Certain serine proteases from the circulation (e.g., coagulation factors), inflammatory cells (e.g., mast-cell tryptase, neutrophil proteinase 3), and from many other cell types (e.g., trypsins) can specifically signal to cells by cleaving protease-activated receptors (PARs), a family of four G

Protease-activated receptor 2: activation, signalling and function.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
PARs (protease-activated receptors) are a family of four G-protein-coupled receptors for proteases from the circulation, inflammatory cells and epithelial tissues. This report focuses on PAR(2), which plays an important role in inflammation and pain. Pancreatic (trypsin I and II) and extrapancreatic

Increased basal transepidermal water loss leads to elevation of some but not all stratum corneum serine proteases.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
There are indications of elevation of some inflammatory serine proteases in barrier damaged skin (e.g. plasmin and urokinase). Moreover, many other serine protease activities are present such as desquamatory enzymes as well as a newly detected tryptase-like serine protease. However, the activities

Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de grado.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
This study was designed to determine if the Amazonian medicinal sangre de grado, confers benefit by suppressing the activation of sensory afferent nerves. METHODS (i) vasorelaxation of rat mesenteric arteries in response to calcitonin gene-related peptide; (ii) rat paw edema in response to protease-

Effect of protease-activated receptor 2 activation on single TRPV1 channel activities in rat vagal pulmonary sensory neurons.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Protease-activated receptor 2 (PAR(2)) is involved in airway inflammation and airway hyperresponsiveness; both are the prominent features of asthma. Transient receptor potential vanilloid receptor 1 (TRPV1) is expressed in pulmonary sensory nerves, functions as a thermal and chemical transducer and
This study aimed to investigate the association between naturally occurring spinal osteoarthritis (OA) (L3-L5), the expression of substance P (SP) centrally (L4-L5) and the presence of neurogenic inflammation within the neurosegmentally linked quadriceps (L2-L5) in elderly rats versus

Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Proteases that are released during inflammation and injury cleave protease-activated receptor 2 (PAR2) on primary afferent neurons to cause neurogenic inflammation and hyperalgesia. PAR2-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1

Neurogenic inflammation and pancreatitis.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
Stimulation of primary sensory neurons produces local vasodilation, plasma extravasation, and pain and is due largely to the release of the tachykinins substance P and calcitonin-gene-related peptide. Pathological activation of sensory neurons and the inflammatory sequelae are known as neurogenic

Protease-activated receptor 2 in dorsal root ganglion contributes to peripheral sensitization of bone cancer pain.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
BACKGROUND Treating bone cancer pain continues to be a major clinical challenge, and the underlying mechanisms of bone cancer pain remain elusive. Protease-activated receptor 2 (PAR2) has been reported to be involved in neurogenic inflammation, nociceptive pain and hyperalgesia. Here, we

Skin neurogenic inflammation.

Csak regisztrált felhasználók fordíthatnak cikkeket
Belépés Regisztrálás
The epidermis closely interacts with nerve endings, and both epidermis and nerves produce substances for mutual sustenance. Neuropeptides, like substance P (SP) and calcitonin gene-related protein (CGRP), are produced by sensory nerves in the dermis; they induce mast cells to release vasoactive
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