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BACKGROUND OF THE DISCLOSURE
Epidermal growth factor receptor (EGFR), also known as ErbB1 or HER-1, is a cell surface receptor that plays a major role in a variety of cellular responses. It is a member of four closely related receptor tyrosine kinases: ErbB1, ErbB2 (HER-2), ErbB3 (HER-3), ErbB4
FIELD OF THE INVENTION
The present invention relates to inhibitors of dipeptidyl peptidase IV and dipeptidyl peptidase IV-like enzyme activity and, more particularly, pharmaceutical compositions containing said compounds, and the use of said compounds for the treatment of cancer and tumors. The
FIELD OF THE INVENTION
The present invention relates to inhibitors of dipeptidyl peptidase IV and dipeptidyl peptidase IV-like enzyme activity and, more particularly, pharmaceutical compositions containing said compounds, and the use of said compounds for the treatment of cancer and tumors. The
FIELD OF THE INVENTION
The present invention relates generally to the field of medicine, and relates specifically to angiogenesis and metastasis of cancer tissues. Specifically the invention relates to the use of antagonists of the serine integral membrane protease, dipeptidyl peptidase IV (DPPIV
BACKGROUND
1. Technical Field
This document relates to methods and materials involved in assessing chemotherapy responsiveness and treating cancer (e.g., breast cancer). For example, this document provides methods and materials for determining whether or not a cancer patient (e.g., a breast cancer
FIELD OF THE INVENTION
This invention relates to the field of immunology. In particular, it relates to peptides which form complexes with HLA molecules, and exhibit a half-life of more than 30 minutes relative to degradation by peptidase. More particularly, the present invention contemplates a class
FIELD OF THE INVENTION
This invention relates to the field of immunology. In particular, it relates to peptides which form complexes with HLA molecules, and exhibit a half-life of more than 30 minutes relative to degradation by peptidase. More particularly, the present invention contemplates a class
CROSS-REFERENCE TO RELATED APPLICATIONS
The present application is a U.S. National Stage of International Application No. PCT/EP2004/011644, filed Oct. 15, 2004, which claims priority of German Patent Application No. 103 48 044.7, filed Oct. 15, 2003.
The present invention relates to novel
FIELD OF THE DISCLOSURE
The present invention relates generally to the field of human health, and in particular to methods for the prophylaxis and treatment of cancers and/or other conditions that are positively correlated with the expression of ErbB2.
BACKGROUND OF THE INVENTION
ErbB2, also known
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a National Stage Application of PCT/GB2016/052130 filed Jul. 14, 2016, which claims priority from UK Patent Application No. 1512270.8, filed on Jul. 14, 2015 and UK Patent Application No. 1604642.7, filed on Mar. 18, 2016. The priority of
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is a National Stage Application of PCT/GB2017/050763 filed Mar. 17, 2017, which claims priority from UK Patent Application. No. 1604647.6, filed on Mar. 18, 2016. The priority of said PCT and UK Patent Application are claimed. Each of the
FIELD OF THE INVENTION
The present invention relates generally to the field of medicine, and relates specifically to angiogenesis and metastasis of cancer tissues, as well as treatment of cardiovascular disease. Specifically the invention relates to the use of modulators, including antagonists and
1. INTRODUCTION
The present invention relates to novel methods for detection and isolation of cancer cells with metastatic potential from blood, ascites and tumor tissue derived from subjects with metastatic cancer. The invention further relates to novel compositions for use as cell-adhesion
1. INTRODUCTION
The present invention relates to novel methods for detection and isolation of cancer cells with metastatic potential from blood, ascites and tumor tissue derived from subjects with metastatic cancer. The invention further relates to novel compositions for use as cell-adhesion
1. INTRODUCTION
The present invention relates to novel methods for detection and isolation of cancer cells with metastatic potential from blood, ascites and tumor tissue derived from subjects with metastatic cancer. The invention further relates to novel compositions for use as cell-adhesion