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Carotenoids and cancer in animal models.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

As evidence accumulated from epidemiological studies that beta-carotene acts as a chemopreventive agent with respect to inhibiting the appearance of certain types of tumors in humans, attention focused on animal models as a means of extending our understanding of carotenoid function. Unfortunately,

Mechanistic understanding of β-cryptoxanthin and lycopene in cancer prevention in animal models.

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Belépés Regisztrálás

To better understand the potential function of carotenoids in the chemoprevention of cancers, mechanistic understanding of carotenoid action on genetic and epigenetic signaling pathways is critically needed for human studies. The use of appropriate animal models is the most justifiable approach to

Antioxidant vitamins and risk of gastric cancer: a case-control study in Portugal.

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Belépés Regisztrálás

We quantified the effect of antioxidant vitamins in gastric cancer risk, taking into account Helicobacter pylori seropositivity and overall fruit and vegetable intake. Incident cases were identified in two large hospitals in Porto, Portugal, and controls were randomly sampled among city dwellers.

Diet and the risk of vulvar cancer.

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Belépés Regisztrálás

In this case-control study, 201 case patients with vulvar cancer and 342 community control subjects responded to a 61-item food frequency questionnaire. Risk was unrelated to intake of dark green vegetables, citrus fruits, legumes, and vitamins A and C and folate. Risk increased modestly with

Diet, tobacco use, and fatal prostate cancer: results from the Lutheran Brotherhood Cohort Study.

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Belépés Regisztrálás

A cohort of 17,633 white males age 35 and older responded to a mailed epidemiological questionnaire in 1966 and was followed until 1986 to determine the risk of cancer associated with diet, tobacco use, and other factors. During the 20-year follow-up, 149 fatal prostate cancer cases were identified.

Antioxidant vitamins and risk of lung cancer.

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Belépés Regisztrálás

Tobacco use is the leading risk factor for lung cancer, yet in addition to smoking habit, diet may also play a role in the disease's appearance. While there are reports to indicate that antioxidant vitamins and carotenoids may decrease the risk of lung cancer, results to date have been somewhat

Dietary carotenoids inhibit neoplastic transformation and modulate gene expression in mouse and human cells.

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Belépés Regisztrálás

Many epidemiologic studies have associated the consumption of diets rich in fruit and green and yellow vegetables with a decreased risk of cancer. Of the many components of such a diet, the content of carotenoids, particularly beta-carotene, has been most consistently linked to decreased risk. The

[The immunological role of carotenoids in the prevention of cancer].

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Epidemiological studies have suggested that the intake of green-yellow vegetables decrease the risk of cancer. Vitamin A, which is abundantly present in green-yellow vegetables in the form of provitamin A, was demonstrated to inhibit chemical and viral-carcinogenesis in experimental animals.

Antiproliferative effect of carotenoids on human colon cancer cells without conversion to retinoic acid.

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Belépés Regisztrálás

The present study employed two human colon cancer cell lines, DLD-1 and Colo 320DM, to investigate whether the provitamin A activity of carotenoids is necessary for their antitumor effect on colon cancer. Carotenoids, including alpha- and beta-carotene and canthaxanthin, significantly suppressed

Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs.

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Belépés Regisztrálás

Expression of connexin 43 (Cx43) is correlated with reduced indexes of neoplasia and is upregulated by cancer-preventive retinoids and carotenoids in nontransformed human and murine fibroblasts and keratinocytes. The molecular mechanism of upregulation, however, is poorly understood. Three retinoic

Lycopene in the prevention of prostate cancer.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Based on the evidence from epidemiologic, animal, and in vitro data and human clinical trials, it is evident that lycopene, a non-provitamin A carotenoid, is a promising agent for prostate cancer chemoprevention. It is also clear that the form of lycopene used (purified versus food sources), dose of

The role of vitamins A, beta-carotene, E and C in cancer cell biology.

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Belépés Regisztrálás

Vitamins A (retinol, retinoids), beta-carotene (provitamin A), E (alpha-tocopherol), and C (ascorbic acid) are used in experimental, clinical and epidemiological studies for cancer chemoprevention and treatment. The cellular and metabolic effects are depending on the dose used, duration of exposure,

Intake of carotenoids and retinol in relation to risk of prostate cancer.

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Belépés Regisztrálás

BACKGROUND Several human studies have observed a direct association between retinol (vitamin A) intake and risk of prostate cancer; other studies have found either an inverse association or no association of intake of beta-carotene (the major provitamin A) with risk of prostate cancer. Data

β-Cryptoxanthin Reduced Lung Tumor Multiplicity and Inhibited Lung Cancer Cell Motility by Downregulating Nicotinic Acetylcholine Receptor α7 Signaling.

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Belépés Regisztrálás

Despite the consistent association between a higher intake of the provitamin A carotenoid β-cryptoxanthin (BCX) and a lower risk of lung cancer among smokers, potential mechanisms supporting BCX as a chemopreventive agent are needed. We first examined the effects of BCX on 4-[methyl

Beta-carotene-Encapsulated Solid Lipid Nanoparticles (BC-SLNs) as Promising Vehicle for Cancer: an Investigative Assessment.

Csak regisztrált felhasználók fordíthatnak cikkeket

Belépés Regisztrálás

Beta-carotene (BC), a red-colored pigment found in plants and animals, is one of the most extensively investigated carotenoids due to its provitamin-A, antioxidant, and anticancer properties. The anticancer activity of BC through oral administration is severely affected due to its low

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