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The baculovirus/insect cell system has proven to be a powerful tool for the expression of eukaryotic proteins. Therapeutics, especially in the field of vaccinology, are often composed of several different protein subunits. Conventional baculoviral expression schemes largely lack efficient strategies
Many viruses require the host endoplasmic reticulum protein-folding machinery in order to correctly fold one or more of their glycoproteins. Iminosugars with glucose stereochemistry target the glucosidases which are key for entry into the glycoprotein folding cycle. Viral glycoproteins are thus
MicroRNAs (miRNAs) have recently been found to be critical regulators of metabolic homeostasis. A study in Nature by Trajkovski et al. (2011) shows that the highly related miRNAs miR-103 and miR-107 modulate insulin sensitivity and glucose homeostasis in obese mice. These miRNAs might represent
Exemplified by the cancer cell's preference for glycolysis (the Warburg effect), altered metabolism has taken centerstage as an emerging hallmark of cancer. Charting the landscape of cancer metabolic addictions should reveal new avenues for therapeutic attack. Two recent studies found subsets of
A pivotal metabolic function of insulin is the stimulation of glucose uptake into muscle and adipose tissues. The discovery of the insulin-responsive glucose transporter type 4 (GLUT4) protein in 1988 inspired its molecular cloning in the following year. It also spurred numerous cellular mechanistic
A 67-year-old patient with newly diagnosed acute myeloid leukemia developed acute respiratory failure with high-grade fever and bilateral pulmonary infiltrates. Blood cultures were sterile and no bacterial or fungal pathogen was identified in the endotracheal aspirate. The patient did not respond to
BACKGROUND
Sweet syndrome is the most common neutrophilic dermatosis. We studied its natural history and epidemiologic, clinical, and therapeutic characteristics from a series of 54 cases.
METHODS
This retrospective study examines 54 cases collected over a 10-year-period. Diagnosis was based on
Ninety-three consecutive outpatients receiving tricyclic antidepressants for at least one month were asked about medication side effects, including excessive appetite and craving for sweets. Prevalence of these side effects and their relationship (Pearson r) to type of medication, dosage, patient
Sweet's syndrome is an acute febrile neutrophilic dermatosis. Classical form occurs after infection of the gastrointestinal or respiratory tract. This syndrome is often associated with myeloproliferative disorders and solid tumors. Some cases are reported in the literature in which usage of
Accumulating data suggest an important role of tumor metabolism during cancer development, metastasis, and therapeutic resistance. In Cell Metabolism, Cascone et al. (2018) show that increased tumor glycolysis suppresses anti-tumor immunity by impairing T cell killing and trafficking to the tumor
The extent to which an individual engages in a cognitive task is associated with performance in laboratory settings(1) and a variety of domains of functioning, such as athletic activity and artistic expression.(2) The neural circuitry associated with task engagement is in the process of being
In eukaryotes, the combinatorial potential of carbohydrates is used for the modulation of protein function. However, despite the wealth of cell wall and surface-associated carbohydrates and glycoconjugates, the accepted dogma has been that prokaryotes are not able to glycosylate proteins. This has
OBJECTIVE
To study the clinical, histopathological and therapeutic features of Sweet syndrome with myelodysplastic syndrome (MDS).
METHODS
The clinical data of 3 patients with Sweet syndrome and MDS diagnosed at Peking Union Medical College Hospital between October 1988 and November 2015 were