[A study on the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia].

OBJECTIVE

To investigate the relationship between glutathione S-transferases gene polymorphism and susceptibility response to hypoxia.

METHODS

In the case-control study, the gene polymorphisms of glutathione S-transferases were tested in Tibetan mountaineers and sea-level Han Chinese by multiple-PCR and PCR-RELP.

RESULTS

The frequency of GSTT1 null genotype was significant different between Tibetan mountaineers and sea-level Han Chinese (P < 0.05), OR = 1.86 (95% CI = 1.01-3.39), and also for GSTP(1-105) mutant genotype in two groups (P < 0.01), OR = 2.19 (95% CI = 1.16-4.13). There was significant difference between A allele and G allele of GSTP(1-105) groups (P < 0.01). There was no difference for GSTM1 null genotype between two groups (P > 0.05), OR = 0.78 (95% CI = 0.43 - 1.42).

CONCLUSIONS

GSTT1 and GSTP(1-105) genotype may be associated with susceptibility response to altitude hypoxia.