[Studies on active substance of anticancer effect in Polygonum cuspidatum].

OBJECTIVE

To supply the scientific basis of research and development of the medicinal value of Polygonum cuspidatum.

METHODS

One composition was isolated from the roots of Polygonum cuspidatum by cytotoxicity based fractionation and identified by HPLC-MS, UV scanning and IR. The inhibition and morphology of L-02, Hep G2, SHZ-888, MCF-7, MCF-7/ADM cells growth caused by this composition was determined by MTT assay and HE dyeing.

RESULTS

This composition was identified as trans-and cis-resveratrol. It could specifically inhibit proliferation of many cancer cells but not human normal liver cell. We investigated the cytotoxicity of resveratrol to adriamycin-resistant MCF-7 cell in virtro.

CONCLUSIONS

Resveratrol is a new anticancer composition which is less toxicity and higher efficiency in Polygonum cuspidatum.