[Studies on chemical constituents in the anti-myocardial ischemia effective fraction of Corydalis yanhusuo].

OBJECTIVE

To study the chemical constituents in the anti-myocardial ischemia effective fraction of Corydalis yanhusuo.

METHODS

Compounds were isolated and purified by a macroporous resin, Sephadex LH-20, ODS column chromatography, and prepared TLC. Their structures were identified by spectral analysis and chemical evidence.

RESULTS

Nine compounds, tetrahydrocolumbamine (1), noroxyhydrastinine (2), corunine (3), dehydrocorydaline (4), dehydrocorybulbine (5), columbamine (6), coptisine (7), berberine (8), palmatine (9) were isolated and identified from the effective fraction of Corydalis yanhusuo.

CONCLUSIONS

Compounds 2, 3 and 5 were isolated from this plant for the first time.