Thalictrum foliolosum DC, a perennial flowering herb belonging to family Ranunculaceae and traditionally used as a tonic, antiperiodic, diuretic, febrifuge, purgative and stomachic and for the treatment of snakebite, jaundice, rheumatism, etc. AIM OF THE STUDY: To provide a critical assessment of the state-of-the-art related to the traditional uses, phytochemistry and pharmacology of T. foliolosum with the ultimate objective of providing further research strategies and to facilitate the exploitation of the therapeutic potential of T. foliolosum for the treatment of human disorders.Exhaustive bibliographic research related to T. foliolosum plant was carried out using scientific research engines and databases like Google Scholar, PubMed, Science direct, Royal Society of Chemistry, and American chemical society.Several alkaloids such as Berberine, Jatrorrhizine, Palmatine, Thalrugosidine, Thalrugosaminine, Thalisopine (Thaligosine), Thalirugidine, Thalirugine, 8-Oxyberberine (Berlambine), Noroxyhydrastinine, N, O, O-Trimethylsparsiflorine, Thalicarpine, Thalidasine, Thalfoliolosumines A and Thalfoliolosumines B have been reported from T. foliolosum. Ethnomedicinal studies revealed much wider scope of T. foliolosum in developing various drugs to solve multiple challenges in the health sector. Therapeutic effects are attributed to the bioactivities of the phytocompounds present in T. foliolosum.T. foliolosum is a wonder herb and can be used as an alternative source for berberine and other benzylisoquinoline alkaloids. T. foliolosum could be used as an excellent source of safer and effective herbal remedy for various human ailments since there are no reports of toxicity of this herb.