Triterpenoids and lignans from Schisandra chinensis and their inhibition activities of Cdc25A/B phosphatases

Three new highly modified lanostane triterpenoids schisanchinlactone A-C (1-3), together with six known compounds (4-9) were isolated from the stems and leaves of Schisandra chinensis. Their structures were established by extensive spectroscopic analyses. Compounds 7 and 8 showed significant inhibition of Cdc25A phosphatase with inhibitory rates of 85.5% and 98.1%, respectively, at the concentration of 100 μM.

Keywords: Schisandra chinensis; Cdc25A/B phosphatases; lignan; triterpenoid.