7 արդյունքներ
DESIGN / PHASE Prospective, single-center, randomized, parallel group, double-blind, placebo controlled, phase IIa study STUDY PLANNED DURATION First patient First visit Year 1 1Q
Last patient First visit Year 2 4Q Last patient Last visit Year 3 2Q
CENTER(S)
- COUNTRY(IES) 1 center in 1 country
Alcohol withdrawal syndrome (AWS) is a frequent and potentially fatal outcome. It is crucial to treat AWS in order to reduce symptoms severity, to prevent severe complications and to increase patient motivation to maintain long-term alcohol abstinence. Clarify the relevance of oral magnesium
Diagnosis: The diagnosis of Alcoholic hepatitis is made by the following criteria (12)
I. Chronic active alcohol abuse - >80 grams in males and > 60 grams in females for > 5 years for developing Alcoholic Cirrhosis (13) Alcohol use will be evaluated with the AUDIT score (EASL guidelines (14) II.
Severe alcoholic hepatitis is associated with significant morbidity and mortality.
Diagnosis: The diagnosis of (AH) is made by the following criteria11
I.Chronic active alcohol abuse - > 80 grams in males and > 20 grams in females. II. Duration of jaundice < 3 months III. Serum Bilirubin >5 mg/dl
We have performed experimental studies demonstrating the anti-cancer efficacy of an old alcoholism treatment drug, disulfiram, combined with supplementation with certain metal ions. Together, disulfiram and metal ions induce S-glutathionylation of critical cancer cell proteins, inhibiting their
Primary and Secondary Efficacy Measures Primary
Change from baseline in:
• Mean composite pain scores (on IVRS) Secondary
Change from baseline in:
- Associated symptoms of IBS (diarrhea, constipation, incomplete emptying, etc.) scores
- IBS Quality of Life scores
- Clinical Global Impression scores
INTRODUCTION
BACKGROUND: In recent years, the need to achieve increasingly ambitious therapeutic goals for dyslipidemias has prompted the search for more potent pharmacological agents to lower circulating atherogenic lipoprotein concentrations and enhance reverse cholesterol transport (RCT). While