Էջ 1 սկսած 172 արդյունքներ
BACKGROUND OF THE INVENTION
The invention relates to a method for risk stratification for acute coronary syndrome (ACS), in particular acute myocardial infarction (AMI) and angina pectoris (AP), wherein provasopressin (proAVP) or fragments and partial peptides thereof, in particular copeptin or
BACKGROUND OF THE INVENTION
The invention relates to a method for risk stratification for acute coronary syndrome (ACS), in particular acute myocardial infarction (AMI) and angina pectoris (AP), wherein provasopressin (proAVP) or fragments and partial peptides thereof, in particular copeptin or
The present invention relates to imidazole derivatives and salts thereof, to their synthesis and intermediates therefor, to pharmaceutical formulations containing such compounds and to the use of these compounds in medicine.
Thromboxane A.sub.2 (TXA.sub.2), a potent stimulator of blood platelet
The present invention relates to a pharmaceutical composition comprising as active ingredients
(i) the AT.sub.1 receptor antagonist (S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'(1H-tetrazol-5-yl)bi phenyl-4-yl-methyl]amine (valsartan) of formula (I) ##STR1##
or a pharmaceutically acceptable
The present invention relates to a pharmaceutical composition comprising as active ingredients
(i) the AT.sub.1 receptor antagonist (S)-N-(1-carboxy-2-methyl-prop-1-yl)-N-pentanoyl-N-[2'(1H-tetrazol-5-yl)bi phenyl4-yl-methyl]amine (valsartan) of formula (I) ##STR1##
or a pharmaceutically acceptable
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is the U.S. National Stage of International Application No. PCT/KR2011/006065, filed Aug. 18, 2011, which claims priority to and the benefit of Korean Patent Application No. 10-2010-0079857, filed Aug. 18, 2010, which is hereby incorporated by
BACKGROUND OF THE INVENTION
The renin angiotensin system is a complex hormonal system comprised of a large molecular weight precursor, angiotensinogen, two processing enzymes, renin and angiotensin converting enzyme (ACE), and the vasoactive mediator angiotensin II (Ang II). See J. Cardiovasc.
BACKGROUND OF THE INVENTION
The renin angiotensin system is a complex hormonal system comprised of a large molecular weight precursor, angiotensinogen, two processing enzymes, renin and angiotensin converting enzyme (ACE), and the vasoactive mediator angiotensin II (Ang II). See J. Cardiovasc.
The invention relates to semicarbazides of the general formula I, ##STR2##
where: R.sup.1 is --(CH.sub.2).sub.n --NH.sub.2, --CON.dbd.C(NH.sub.2).sub.2, --NHC(.dbd.NH)--NH.sub.2 or --C(.dbd.NH)--NH.sub.2, which can also be monosubstituted by --OH, --OCOOA, --OCOO(CH.sub.2).sub.n N(A).sub.2,
The present invention relates to acylated indanyl amines of the general formula (I), with the definitions of R.sup.1 to R.sup.5 and A and B given below in the text, in any of their stereoisomeric forms or mixtures thereof in any ratio and/or pharmaceutically acceptable salts thereof, and their use
The present invention relates to acylated indanyl amines of the general formula (I), with the definitions of R.sup.1 to R.sup.5 and A and B given below in the text, in any of their stereoisomeric forms or mixtures thereof in any ratio and/or pharmaceutically acceptable salts thereof, and their use
The present invention relates to acylated indanyl amines of the general formula (I), with the definitions of R.sup.1 to R.sup.5 and A and B given below in the text, in any of their stereoisomeric forms or mixtures thereof in any ratio and/or pharmaceutically acceptable salts thereof, and their use
FIELD OF THE INVENTION
The present invention relates to a novel peptide which has endothelin-antagonizing activity, and an intermediate for its synthesis. The peptide has excellent endothelin-antagonizing activity, and is therefore useful for treatment of hypertension, asthma, cerebral apoplexy,
SUMMARY OF THE INVENTION
The Scope of Composition
This invention relates to dihydrothiaphenanthrenecarbonylguanidines of formula I, encompassing their composition, process of making, and use as medicament or diagnostic aid. ##STR2##
wherein, R1 and R3 are independently selected from the group
RELATED APPLICATIONS
This application is a national stage application (under 35 U.S.C. .sctn.371) of PCT/DE2007/002313, filed Dec. 22, 2007, which claims benefit of German application 102006060835.6, filed Dec. 22, 2006.
The invention relates to a method for diagnosis and/or risk classification of