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A new benzylisoquinoline alkaloid, lincangenine-4-β-D-glucopyranoside (1), has been isolated from the roots of Leontice altaica, together with 5 known alkaloids. Its structure was elucidated on the basis of 1D and 2D NMR data, and chemical means.
1. The effects of (-)oblongine chloride, a quaternary alkaloid from Leontice leontopetalum, on guinea-pig isolated ileal longitudinal segments, main pulmonary artery rings, spontaneously-beating atrium and isolated perfused heart were studied. 2. Oblongine chloride (3 x 10(-5)-10(-3) M) caused
1. Low concentrations of petaline chloride (1-300 micrograms/ml) caused relaxation of the epinephrine-contracted aorta, contraction of the ileum, and no effect on the trachea. 2. Larger concentrations (up to 3 mg/ml) caused nonsustained large contractions of the aorta and the trachea and increased